{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T12:02:15Z","timestamp":1789214535868,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterised by immune\u2010mediated platelet destruction, yet its metabolic underpinnings remain incompletely understood. In this study, we applied a non\u2010targeted serum metabolomics approach to characterise metabolic alterations in ITP and to explore candidate diagnostic biomarkers. A total of 37 serum samples were collected, including 20 from patients with ITP and 17 from age\u2010 and sex\u2010matched healthy individuals. Global metabolite profiling was performed, followed by quantitative analyses, identification of differentially expressed metabolites, and functional annotation. Machine learning algorithms were then used to construct a diagnostic prediction model based on differential metabolites. Compared with healthy controls, ITP patients exhibited a distinct metabolic signature dominated by alterations in lipids and lipid\u2010like molecules, with 680 metabolites upregulated and 589 downregulated. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed prominent involvement of lipid metabolism, cholesterol metabolism, and unsaturated fatty acid metabolism pathways. Among the differential metabolites, isopimpinellin and oleic acid emerged as highly characteristic of ITP. The prediction model built on these metabolomic features achieved a sensitivity of 78%, a specificity of 100%, and an area under the receiver operating characteristic curve of 0.83, indicating promising diagnostic performance. These findings suggest that dysregulated lipid metabolism is a central feature of ITP and support the potential of serum metabolomics\u2010based machine learning models to aid in the identification of novel biomarkers and to improve early diagnosis of this immune\u2010mediated thrombocytopenia.<\/jats:p>","DOI":"10.1111\/sji.70077","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T04:26:12Z","timestamp":1765513572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Untargeted Metabolomic Profiling Reveals Lipid Metabolism Dysregulation in Patients With Immune Thrombocytopenia"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6802-8863","authenticated-orcid":false,"given":"Xin","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Hematology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Hematology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengran","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6521-231X","authenticated-orcid":false,"given":"Ningning","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Hematology Shandong Provincial Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"},{"name":"Department of Hematology The Second Hospital of Shandong University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.613192"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1499014"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13226738"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2021.1995347"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25042163"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107803"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122137"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2017.07.001"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00781-x"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01954-6"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.828191"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.938535"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2024.103738"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19391"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023012541"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01401-z"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19229"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-023-00551-x"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12905"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2024.102342"},{"issue":"1","key":"e_1_2_14_22_1","article-title":"A Retrospective Study of Risk Factors for Thrombosis in Patients With ITP","volume":"30","author":"Zhou F.","year":"2025","journal-title":"Hematology (Amsterdam, Netherlands)"},{"issue":"4","key":"e_1_2_14_23_1","first-page":"430","article-title":"The Causal Effect of 179 Plasma Lipid Groups on Immune Thrombocytopenia: A Mendelian Randomized Study","volume":"54","author":"Li J.","year":"2024","journal-title":"Annals of Clinical and Laboratory Science"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ele.13771"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168974"},{"issue":"12","key":"e_1_2_14_26_1","article-title":"Lipid Droplets, Phospholipase A2, Arachidonic Acid, and Atherosclerosis","volume":"9","author":"Berm\u00fadez M. A.","year":"2021","journal-title":"Biomedicine"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/membranes12020182"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-631259"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-023-00545-9"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13794"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.864995"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.860586"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.279770"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2023.2182180"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023012018"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.04.001"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-11488-6_7"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.TR119000267"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-54093-5"},{"issue":"3","key":"e_1_2_14_40_1","first-page":"184","article-title":"Lipid Profile and Atherogenic Indices and Their Association With Platelet Indices in Familial Mediterranean Fever","volume":"46","author":"\u00c7ak\u0131rca G.","year":"2018","journal-title":"Turk Kardiyoloji Dernegi Arsivi: Turk Kardiyoloji Derneginin Yayin Organidir"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P037614"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12511"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010975"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvab050"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4280-9"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01853"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(17)30170-9"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13184"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abn9061"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-05-784413"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-10-0881"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.70077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/sji.70077","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.70077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:09:13Z","timestamp":1769832553000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sji.70077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/sji.70077"],"URL":"https:\/\/doi.org\/10.1111\/sji.70077","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70077"}}