{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T18:11:49Z","timestamp":1769883109032,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Multiple sclerosis (MS) is a prevalent autoimmune disease with increasing incidence in certain populations, and autologous haematopoietic stem cell transplantation (aHSCT) represents an important therapeutic option. Cytomegalovirus (CMV) has been implicated in the pathophysiology of several immune\u2010mediated conditions, prompting evaluation of its potential influence on transplant outcomes. We analysed MS patients who underwent aHSCT between 2015 and 2023 with 12\u2010month follow\u2010up using the \u2018Mexican method,\u2019 assessing clinical response through the change in Expanded Disability Status Scale (EDSS) score from pre\u2010transplant to 12\u2009months post\u2010procedure. Among 135 patients, 93 were classified as responders and 42 as non\u2010responders. Lower pre\u2010transplant EDSS was associated with a better response (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), and women showed significantly greater improvement following aHSCT (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.012). Higher serum IgG anti\u2010CMV levels correlated with improved clinical outcomes (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021), suggesting that prior CMV exposure may be linked to enhanced response to aHSCT. These findings highlight a potential modulatory role of CMV serostatus in transplant efficacy and support the need for further studies to clarify the biological basis and clinical relevance of this association.\n                  <\/jats:p>","DOI":"10.1111\/sji.70078","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T05:44:46Z","timestamp":1764740686000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Citomegalovirus Serology and Response to Autologous Haematopoietic Stem Cell Transplantation in Persons With Multiple Sclerosis"],"prefix":"10.1111","volume":"102","author":[{"given":"Luis Enrique","family":"Hamilton\u2010Avil\u00e9s","sequence":"first","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna, Cl\u00ednica Ruiz  Puebla M\u00e9xico"},{"name":"Universidad Popular Aut\u00f3noma del Estado de Puebla  Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mois\u00e9s Manuel","family":"Gallardo\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna, Cl\u00ednica Ruiz  Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda","family":"Melgar\u2010de\u2010la\u2010Paz","sequence":"additional","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna, Cl\u00ednica Ruiz  Puebla M\u00e9xico"},{"name":"Universidad An\u00e1huac Puebla  Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Negrete\u2010Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna, Cl\u00ednica Ruiz  Puebla M\u00e9xico"},{"name":"Universidad de Las Am\u00e9ricas Puebla  Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria Erendy","family":"Cruz\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna, Cl\u00ednica Ruiz  Puebla M\u00e9xico"},{"name":"Universidad Popular Aut\u00f3noma del Estado de Puebla  Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danae","family":"Garc\u00eda\u2010V\u00e9lez","sequence":"additional","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna, Cl\u00ednica Ruiz  Puebla M\u00e9xico"},{"name":"Universidad Popular Aut\u00f3noma del Estado de Puebla  Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Oca\u00f1a\u2010Ramm","sequence":"additional","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna, Cl\u00ednica Ruiz  Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sof\u00eda Ch\u00e1vez","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna, Cl\u00ednica Ruiz  Puebla M\u00e9xico"},{"name":"Universidad Popular Aut\u00f3noma del Estado de Puebla  Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Olivares\u2010Gazca","sequence":"additional","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna, Cl\u00ednica Ruiz  Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo J.","family":"Ruiz\u2010Delgado","sequence":"additional","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna, Cl\u00ednica Ruiz  Puebla M\u00e9xico"},{"name":"Universidad Popular Aut\u00f3noma del Estado de Puebla  Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo J.","family":"Ruiz\u2010Arg\u00fcelles","sequence":"additional","affiliation":[{"name":"Centro de Hematolog\u00eda y Medicina Interna, Cl\u00ednica Ruiz  Puebla M\u00e9xico"},{"name":"Universidad Popular Aut\u00f3noma del Estado de Puebla  Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2020.05.049"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-019-00765-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.935949"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0285-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens14070629"},{"key":"e_1_2_8_7_1","unstructured":"\u201cExpanded Disability Status Scale (EDSS) MS Society \u201d[citado el 3 de noviembre de 2025] https:\/\/www.mssociety.org.uk\/living\u2010with\u2010ms\/treatments\u2010and\u2010therapies\/getting\u2010treatment\u2010for\u2010ms\/expanded\u2010disability\u2010status\u2010scale."},{"key":"e_1_2_8_8_1","unstructured":"\u201cExpanded Disability Status Scale (EDSS) MS Trust \u201d(2024) [citado el 3 de noviembre de 2025] 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