{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:24:16Z","timestamp":1790976256634,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Immune dysregulation is involved in Parkinson's disease (PD), but the roles of C\u2010X\u2010C motif chemokine receptor 3 (CXCR3)\/chemokine receptor 6 (CXCR6) on T cells and their correlation with peripheral inflammation remain unclear. This study investigated their expression on peripheral blood T cells and correlation with inflammation in PD. A total of 36 PD patients and 26 healthy controls were enrolled; their clinical information and laboratory test results (including the systemic immunoinflammatory index [SII], neutrophil\u2010to\u2010lymphocyte ratio [NLR], monocyte\u2010to\u2010lymphocyte ratio [MLR], platelet\u2010to\u2010lymphocyte ratio [PLR], monocyte\u2010to\u2010high\u2010density lipoprotein ratio [MHR], and erythrocyte distribution width over platelets ratio [RPR]) were recorded. Meanwhile, a multicolour flow cytometry protocol using six cell surface antibodies (CD3, CD4, CD8, CD45RO, CXCR3, and CXCR6) was applied. The results showed that CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells were significantly reduced in the PD group compared with healthy controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and CXCR3 expression was significantly increased on peripheral blood CD4\n                    <jats:sup>+<\/jats:sup>\n                    effector T cells and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells of PD patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Additionally, CXCR6 expression was significantly elevated on cytotoxic T lymphocytes (CTLs) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) but showed no significant difference on CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells between PD patients and controls (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). Compared with healthy controls, PD patients had significantly increased peripheral blood C\u2010reactive protein (CRP) levels (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) but remarkably decreased monocytes, lymphocytes, and MHR (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Collectively, the upregulated expression of CXCR3 and CXCR6 predominantly on CD8\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes may contribute to PD pathogenesis, though no significant correlation between the expression of these receptors and peripheral inflammation was observed.\n                  <\/jats:p>","DOI":"10.1111\/sji.70090","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T04:33:02Z","timestamp":1770611582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of\n                    <scp>CXCR3<\/scp>\n                    and\n                    <scp>CXCR6<\/scp>\n                    on Circulating T Cells in Patients With Parkinson's Disease"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4130-9122","authenticated-orcid":false,"given":"Yufeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Medical School of Chinese PLA  Beijing China"},{"name":"Department of Neurology, the First Medical Center Chinese PLA General Hospital  Beijing China"},{"name":"Department of Neurology, the Eighth Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuangzhuang","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Eighth Medical Center Chinese PLA General Hospital  Beijing China"},{"name":"Navy Clinical College, the Fifth School of Clinical Medicine Anhui Medical University  Hefei Anhui China"},{"name":"State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Neurology, the Eighth Medical Center Chinese PLA General Hospital  Beijing China"},{"name":"State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases  Beijing China"},{"name":"Department of Neurology Huaihe Hospital of Henan University  Kaifeng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6084-3275","authenticated-orcid":false,"given":"Jinming","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9151-7264","authenticated-orcid":false,"given":"Xiaoling","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Neurology, the First Medical Center Chinese PLA General Hospital  Beijing China"},{"name":"Department of Neurology, the Eighth Medical Center Chinese PLA General Hospital  Beijing China"},{"name":"State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases  Beijing China"},{"name":"Department of Nephrology, the First Medical Center Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases  Beijing China"},{"name":"Department of Nephrology, the First Medical Center Chinese PLA General Hospital  Beijing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6931-1219","authenticated-orcid":false,"given":"Feng","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Neurology, the First Medical Center Chinese PLA General Hospital  Beijing China"},{"name":"Department of Neurology, the Eighth Medical Center Chinese PLA General Hospital  Beijing 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