{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:42:41Z","timestamp":1789501361087,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In recent years, neutrophil extracellular traps (NETs) have attracted widespread attention due to their roles in immune response and inflammation. Platelets have been shown to play a dual role as both stimulators and responders in the formation of NETs. In this review, we comprehensively describe the molecular mechanisms underlying the interactions between NETs and platelets. Additionally, as both NETs and platelets serve as key mediators in sepsis, we will also discuss their regulatory functions in sepsis, aiming to provide new approaches and insights for the prevention, diagnosis, and treatment of sepsis.<\/jats:p>","DOI":"10.1111\/sji.70120","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:40:36Z","timestamp":1778902836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Molecular Mechanisms of\n                    <scp>NETs<\/scp>\n                    and Platelet Interactions and Their Regulatory Functions in Sepsis"],"prefix":"10.1111","volume":"103","author":[{"given":"Zhongji","family":"Han","sequence":"first","affiliation":[{"name":"Emergency Medicine Department the Second Affiliated Hospital of Shandong First Medical University  Tai'an City Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Emergency Medicine Department the Second Affiliated Hospital of Shandong First Medical University  Tai'an City Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maokui","family":"Yue","sequence":"additional","affiliation":[{"name":"Emergency Medicine Department the Second Affiliated Hospital of Shandong First Medical University  Tai'an City Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens5010032"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541\u20107786.Mcr\u201025\u20100615"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24055034"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25053025"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2020.126644"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.850416"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12195\u2010016\u20100469\u20100"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1500259"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2020.09.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114934"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/jir.S504184"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3345"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70101"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00189\u201025"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1134\/s0006297920100065"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000675"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2847"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14050335"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2025.09.002"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100044\u20101791512"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1442613"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105381.2008.00021.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201001\u2010624023"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929\u2010022\u201000832\u2010z"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1565"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186981"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102005\u201006\u20102202"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26010143"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.Mr0618\u2010213r"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/jir.S394927"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2020.1718631"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2100593"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1475543"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12710"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.171054"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102011\u201003\u2010343061"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201061309\u20103"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107602"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvae218"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/hs9.0000000000000231"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.483123"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010018\u20100235\u20100"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.183"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115805"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2053"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/aln.0000000000000429"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1160\/th08\u201001\u20100010"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1160\/th07\u201007\u20100474"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030424"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011170"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15852"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.653228"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00085"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01037"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20112322"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700639"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.114.304114"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bvth.2025.100091"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102014\u201007\u2010587709"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.70120","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/sji.70120","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.70120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:10:38Z","timestamp":1779351038000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sji.70120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/sji.70120"],"URL":"https:\/\/doi.org\/10.1111\/sji.70120","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70120"}}