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Single\u2010nucleotide polymorphisms (SNPs) are common single\u2010base genomic variants that are frequent, stable and readily detectable, making them useful markers for studying genetic susceptibility to disease. Specific SNPs may contribute to immune abnormalities, bone marrow microenvironmental imbalance and dysfunction of haematopoietic stem and progenitor cells (HSPCs) in AA by regulating gene expression and influencing molecular functions. 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