{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:45:44Z","timestamp":1791791144910,"version":"4.3.4"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lymphoproliferation is a common manifestation of inborn errors of immunity and may delay diagnosis when it is the initial presentation. A nine\u2010year\u2010old girl developed recurrent lymphadenopathy from two years of age, accompanied by recurrent infections, anaemia and growth retardation. Whole\u2010exome sequencing identified a homozygous\n                    <jats:italic>PRKCD<\/jats:italic>\n                    missense variant. Lymph node biopsy revealed florid follicular hyperplasia with cytomegalovirus (CMV) activation, and CMV viremia was detected. Despite immunoglobulin replacement, valganciclovir and immunomodulatory therapy, lymphoproliferation persisted. Haematopoietic stem cell transplantation was successfully performed, highlighting the importance of early genetic diagnosis and timely curative treatment in these patients.\n                  <\/jats:p>","DOI":"10.1111\/sji.70152","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:56:06Z","timestamp":1791788166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent Infections and Refractory Lymphoproliferation Associated With a Novel\n                    <scp>PRKCD<\/scp>\n                    Variant: A Case Report of Successful Haematopoietic Stem Cell Transplantation"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1346-503X","authenticated-orcid":false,"given":"B\u00fc\u015fra","family":"Ko\u00e7ali","sequence":"first","affiliation":[{"name":"Division of Pediatric Immunology, Department of Pediatrics Hacettepe University Medical School  Ankara T\u00fcrkiye"},{"name":"\u0130hsan Do\u011framac\u0131 Children's Hospital Hacettepe University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0562-9863","authenticated-orcid":false,"given":"Saliha","family":"Esenbo\u011fa","sequence":"additional","affiliation":[{"name":"Division of Pediatric Immunology, Department of Pediatrics Hacettepe University Medical School  Ankara T\u00fcrkiye"},{"name":"\u0130hsan Do\u011framac\u0131 Children's Hospital Hacettepe University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2329-7543","authenticated-orcid":false,"given":"Elif Soyak","family":"Aytekin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Immunology, Department of Pediatrics Hacettepe University Medical School  Ankara T\u00fcrkiye"},{"name":"\u0130hsan Do\u011framac\u0131 Children's Hospital Hacettepe University  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5278-7456","authenticated-orcid":false,"given":"\u0130smail","family":"Yaz","sequence":"additional","affiliation":[{"name":"Department of Immunology, Pediatric Basic Sciences, Institute of Child Health Hacettepe University  Ankara T\u00fcrkiye"},{"name":"Pediatric Immunology Laboratory, Department of Pediatrics Hacettepe University Medical School  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7062-9393","authenticated-orcid":false,"given":"Ay\u015fe","family":"Demir\u00e7ubuk","sequence":"additional","affiliation":[{"name":"Clinic of Pediatric Hematology and Oncology and Bone Marrow Transplant Unit Medical Point Gaziantep Hospital  Gaziantep T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2691-4826","authenticated-orcid":false,"given":"Ekrem","family":"\u00dcnal","sequence":"additional","affiliation":[{"name":"Clinic of Pediatric Hematology and Oncology and Bone Marrow Transplant Unit Medical Point Gaziantep Hospital  Gaziantep T\u00fcrkiye"},{"name":"Department of Nursing, School of Health Sciences Hasan Kalyoncu University  Gaziantep T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2213-4627","authenticated-orcid":false,"given":"Deniz","family":"\u00c7a\u011fda\u015f","sequence":"additional","affiliation":[{"name":"Division of Pediatric Immunology, Department of Pediatrics Hacettepe University Medical School  Ankara T\u00fcrkiye"},{"name":"\u0130hsan Do\u011framac\u0131 Children's Hospital Hacettepe University  Ankara T\u00fcrkiye"},{"name":"Department of Immunology, Pediatric Basic Sciences, Institute of Child Health Hacettepe University  Ankara T\u00fcrkiye"},{"name":"Pediatric Immunology Laboratory, Department of Pediatrics Hacettepe University Medical School  Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_1_9_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2024.110332","article-title":"Pediatric Lymphoproliferative Disorders Associated With Inborn Errors of Immunity","volume":"266","author":"Cheng J.","year":"2024","journal-title":"Clinical Immunology"},{"key":"e_1_2_1_9_3_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.856601","article-title":"Lymphoproliferation in Inborn Errors of Immunity: The Eye Does Not See What the Mind Does Not Know","volume":"13","author":"Sharma S.","year":"2022","journal-title":"Frontiers in 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R.","year":"2023","journal-title":"Journal of Clinical Immunology"}],"container-title":["Scandinavian Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.70152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/sji.70152","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sji.70152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:56:15Z","timestamp":1791788175000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sji.70152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/sji.70152"],"URL":"https:\/\/doi.org\/10.1111\/sji.70152","archive":["Portico"],"relation":{},"ISSN":["0300-9475","1365-3083"],"issn-type":[{"value":"0300-9475","type":"print"},{"value":"1365-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70152"}}