{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:37:56Z","timestamp":1792741076576,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100010747","name":"Consejo Nacional de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PE501082183\u20102023"],"award-info":[{"award-number":["PE501082183\u20102023"]}],"id":[{"id":"10.13039\/501100010747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tuberculosis (TB) remains a critical global health threat. While research has historically prioritized T\u2010cell immunity, antibodies against highly immunogenic candidates like the\n                    <jats:italic>Mtb<\/jats:italic>\n                    antigen Ag85A are increasingly recognized for their protective roles via Fc\u03b3 receptor\u2010mediated effector functions. This study characterized the longitudinal dynamics of B\u2010cells and phagocyte populations alongside\n                    <jats:italic>Mtb<\/jats:italic>\n                    \u2010specific antibody features during TB treatment. A cohort of 20 patients with active TB was followed prospectively for 6\u2009months, with peripheral blood samples collected at baseline (T0), at two (T2) and 6\u2009months (T6) of therapy. The frequencies of circulating immune cells were analysed by flow cytometry, while Ag85A\u2010specific avidity and phagocytic activity were evaluated in patient plasma. Our findings demonstrate a significant, coordinated shift in the host immune profile during anti\u2010TB therapy. We observed a progressive increase in\n                    <jats:italic>Mtb<\/jats:italic>\n                    \u2010specific phagocytic activity and antibody avidity after treatment completion, indicating a functional remodelling of the immune response. Specifically, Ag85A\u2010specific IgG1 levels correlated with phagocytic activity, suggesting it acts as a primary mediator of this effector response. Concurrently, maturation of antibody avidity correlated negatively with bacillary burden. As bacterial load, quantified by sputum smear test (SST), diminished, we noted a concomitant declining trend in circulating CD14\n                    <jats:sup>+<\/jats:sup>\n                    monocyte and CD66\n                    <jats:sup>+<\/jats:sup>\n                    granulocytes, indicating a gradual resolution of the inflammatory response. Strikingly, this contraction of the myeloid compartment inversely mirrored a progressive rise in circulating B cell frequencies. This integrated framework outperforms conventional metrics, providing a multi\u2010parametric fingerprint that would be used to track treatment responses and design the next generation of TB immunotherapy.\n                  <\/jats:p>","DOI":"10.1111\/sji.70156","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:32:11Z","timestamp":1791264731000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Recovery in Tuberculosis is Associated With the Functional Remodelling of\n                    <scp>Ag85A<\/scp>\n                    \u2010Specific Antibody Avidity and Phagocytic Activity"],"prefix":"10.1111","volume":"104","author":[{"given":"Juan Diego","family":"Jibaja","sequence":"first","affiliation":[{"name":"Laboratorios de Investigaci\u00f3n y Desarrollo, Facultad de Ciencias e Ingenier\u00eda Universidad Peruana Cayetano Heredia  Lima 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