{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:50:58Z","timestamp":1791352258503,"version":"4.3.1"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"publisher","award":["25051018"],"award-info":[{"award-number":["25051018"]}],"id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008368","name":"Gigtforeningen","doi-asserted-by":"publisher","award":["R166\u2010A5554"],"award-info":[{"award-number":["R166\u2010A5554"]}],"id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008368","name":"Gigtforeningen","doi-asserted-by":"publisher","award":["R224\u2010A8313"],"award-info":[{"award-number":["R224\u2010A8313"]}],"id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010306","name":"Direkt\u00f8r Kurt B\u00f8nnelycke og Hustru fru Grethe B\u00f8nnelyckes Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R264\u20102017\u20103344"],"award-info":[{"award-number":["R264\u20102017\u20103344"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scand J Immunol"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lupus nephritis (LN) confers a disproportionate thrombotic risk in systemic lupus erythematosus (SLE) that is not fully explained by conventional cardiovascular risk factors. The underlying molecular mechanisms remain largely unknown. We aimed to characterize the thrombo\u2010inflammatory profiles in LN compared with SLE without nephritis (SLE\u2010NonLN), and contextualized these findings to primary antiphospholipid syndrome (APS), primary Sj\u00f6gren's disease (SjD), and healthy controls. In a cross\u2010sectional design, we included 325 patients with SLE from two Danish cohorts, 10 with primary APS, 45 with primary SjD, and 100 healthy controls. A predefined thrombo\u2010inflammatory panel encompassing endothelial and platelet activation, coagulation, fibrinolysis, and complement pathways was assessed using immunoassays. Group differences were adjusted for clinical covariates and multiple testing. Multivariate patterns were examined using principal component analysis, correlation networks, and logistic regression. Thrombomodulin levels were higher in SLE\u2010LN than in SLE\u2010NonLN and remained associated with LN after multiple testing correction and adjustment for age, treatment exposure, and disease activity. Thrombomodulin showed a modest association with albuminuria but not with disease activity, anti\u2010double\u2010stranded DNA antibody levels, or secondary APS. Correlation networks demonstrated a dense, integrated thrombo\u2010inflammatory structure in SLE\u2010LN. In multivariable logistic regression, thrombomodulin and prednisolone use emerged as independent factors associated with LN. LN is characterized by a distinct thrombo\u2010inflammatory profile dominated by endothelial activation, with thrombomodulin emerging as the most consistent biological marker of renal involvement in SLE. The coordinated alterations observed across multiple pathways highlight the potential value of systems\u2010oriented approaches for advancing mechanistic understanding in LN.<\/jats:p>","DOI":"10.1111\/sji.70158","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:18:03Z","timestamp":1791350283000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thrombomodulin Shapes Thrombo\u2010Inflammatory Interactions in Lupus Nephritis"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8670-0750","authenticated-orcid":false,"given":"Mads Lamm","family":"Larsen","sequence":"first","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"},{"name":"Department of Rheumatology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Medicine Regional Hospital Horsens  Horsens Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2876-0664","authenticated-orcid":false,"given":"Lea Dich","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette Gudmann","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trine Korsgaard","family":"Hejlesen","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Bengtsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Rheumatology Lund University, Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6582-2636","authenticated-orcid":false,"given":"Anne","family":"Voss","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Hauge","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan Due","family":"Kay","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Odense University Hospital  Odense Denmark"},{"name":"Department of Clinical Research University of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7079-1587","authenticated-orcid":false,"given":"Bent","family":"Deleuran","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"},{"name":"Department of Rheumatology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie B.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Clinical Biochemistry Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4817-155X","authenticated-orcid":false,"given":"Steffen","family":"Thiel","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9501-1268","authenticated-orcid":false,"given":"Anne","family":"Troldborg","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"},{"name":"Department of Rheumatology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.39","article-title":"Systemic Lupus Erythematosus","volume":"2","author":"Kaul A.","year":"2016","journal-title":"Nature Reviews. 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G.","year":"2009","journal-title":"Arthritis and Rheumatism"},{"issue":"6","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3899\/jrheum.190250","article-title":"Sj\u00f6gren Syndrome in Systemic Lupus Erythematosus: A Subset Characterized by a Systemic Inflammatory State","volume":"47","author":"Ruacho G.","year":"2020","journal-title":"Journal of Rheumatology"},{"issue":"1","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/art.39859","article-title":"2016 American College of Rheumatology\/European League Against Rheumatism Classification Criteria for Primary Sj\u00f6gren's Syndrome: A Consensus and Data\u2010Driven Methodology Involving Three International Patient Cohorts","volume":"69","author":"Shiboski C. 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