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Little is still known regarding the discriminative validity of the ED diagnosis and how it relates to other diagnostic constructs. The study aimed to investigate the discriminative validity of ED compared with two similar diagnoses, major depressive disorder (MDD) and adjustment disorder (AD). Using data from a sample of patients with a principal diagnosis of either ED (<jats:italic>n<\/jats:italic>\u2009=\u2009352), MDD (<jats:italic>n<\/jats:italic>\u2009=\u200999), or AD (<jats:italic>n<\/jats:italic>\u2009=\u2009302), we compared demographic and clinical variables and scores on self\u2010report symptom scales. Results showed that ED patients were of a higher age and had a higher frequency of sickness absence than MDD and AD patients. There was a substantial overlap of symptoms between ED and MDD, only differing on two of nine self\u2010report symptom scales, with ED patients rating lower work ability <jats:italic>d<\/jats:italic>\u2009=\u2009\u22120.37 and alcohol consumption <jats:italic>d<\/jats:italic>\u2009=\u2009\u22120.57. Compared with AD patients, ED patients reported more severe symptoms in every symptom domain. Given the prevalent use of ED diagnosis, its diagnostic validity and clinical usefulness merit further attention.<\/jats:p>","DOI":"10.1111\/sjop.13087","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T04:49:51Z","timestamp":1733719791000},"page":"315-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exhaustion Disorder in Primary Care: A Comparison With Major Depressive Disorder and Adjustment Disorder"],"prefix":"10.1111","volume":"66","author":[{"given":"Victoria","family":"Sennerstam","sequence":"first","affiliation":[{"name":"Division of Psychology, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Gustavsberg University Primary Care Centre, Academic Primary Health Care Centre  Region Stockholm Stockholm Sweden"},{"name":"Osher Center for Integrative Health, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7939-9848","authenticated-orcid":false,"given":"Erik","family":"Hedman\u2010Lagerl\u00f6f","sequence":"additional","affiliation":[{"name":"Division of Psychology, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Gustavsberg University Primary Care Centre, Academic Primary Health Care Centre  Region Stockholm Stockholm Sweden"},{"name":"Osher Center for Integrative Health, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustav","family":"Nilsonne","sequence":"additional","affiliation":[{"name":"Division of Psychology, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Stress Research Institute, Department of Psychology Stockholm University  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Lekander","sequence":"additional","affiliation":[{"name":"Division of Psychology, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Osher Center for Integrative Health, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Stress Research Institute, Department of Psychology Stockholm University  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"R\u00fcck","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry Research, Department of Clinical Neuroscience Karolinska Institutet, &amp; Stockholm Health Care Services  Region Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Wallert","sequence":"additional","affiliation":[{"name":"Centre for Psychiatry Research, Department of Clinical Neuroscience Karolinska Institutet, &amp; Stockholm Health Care Services  Region Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2562-2925","authenticated-orcid":false,"given":"Erland","family":"Axelsson","sequence":"additional","affiliation":[{"name":"Division of Family Medicine and Primary Care, Department of Neurobiology Care Sciences and Society, Karolinska Institutet  Stockholm Sweden"},{"name":"Liljeholmen University Primary Health Care Centre, Academic Primary Health Care Centre  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elin","family":"Linds\u00e4ter","sequence":"additional","affiliation":[{"name":"Division of Psychology, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Gustavsberg University Primary Care Centre, Academic Primary Health Care Centre  Region Stockholm Stockholm Sweden"},{"name":"Osher Center for Integrative Health, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Centre for Psychiatry Research, Department of Clinical Neuroscience Karolinska Institutet, &amp; Stockholm Health Care Services  Region Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425787"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2013.07.061"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1359105316659917"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006389.pub2"},{"key":"e_1_2_12_6_1","volume-title":"AUDIT\u2010The Alcohol Use Disorders Indentification Test\u2010Guidelines for Use in Primary Care","author":"Babor T. 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