{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:27:58Z","timestamp":1787293678834,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,5,13]],"date-time":"2018-05-13T00:00:00Z","timestamp":1526169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["K23MH090421"],"award-info":[{"award-number":["K23MH090421"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009670","name":"National Alliance for Research on Schizophrenia and Depression","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011142","name":"Graduate School, University of Minnesota","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011142","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Suicide &amp;amp; Life Threat Behav"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Major depressive disorder (<jats:styled-content style=\"fixed-case\">MDD<\/jats:styled-content>) is associated with suicidal thoughts and behaviors (\u201csuicidality\u201d). Of the three components of Joiner's interpersonal theory of suicide, two involve negatively valenced, self\u2010related beliefs: perceived burdensomeness and thwarted belongingness. However, the neurocircuitry underlying self\u2010processing and suicidality has not been fully explored. This study examined the association between suicidality and the neurocircuitry of regions relevant to self\u2010referential processing in adolescents with depression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Fifty\u2010eight adolescents underwent assessment and a resting\u2010state f<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> scan. Resting\u2010state functional connectivity (<jats:styled-content style=\"fixed-case\">RSFC<\/jats:styled-content>) analyses included two brain regions implicated in self\u2010referential processing: precuneus and posterior cingulate cortex (<jats:styled-content style=\"fixed-case\">PCC<\/jats:styled-content>). Suicidality was measured using the Index of Depression and Anxiety Symptoms. While controlling for depression severity, we conducted whole\u2010brain correlation analyses between suicidality and left and right precuneus and <jats:styled-content style=\"fixed-case\">PCC<\/jats:styled-content> connectivity maps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Suicidality was positively associated with <jats:styled-content style=\"fixed-case\">RSFC<\/jats:styled-content> between left precuneus and left primary motor and somatosensory cortices, and middle and superior frontal gyri. Suicidality was negatively associated with <jats:styled-content style=\"fixed-case\">RSFC<\/jats:styled-content> between left <jats:styled-content style=\"fixed-case\">PCC<\/jats:styled-content> and left cerebellum, lateral occipital cortex, and temporal\u2013occipital fusiform gyrus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Findings of hyperconnectivity stemming from the precuneus and hypoconnectivity from the <jats:styled-content style=\"fixed-case\">PCC<\/jats:styled-content> may reflect maladaptive self\u2010reflection and mentalization. However, additional investigation is warranted to further clarify these relationships.<\/jats:p><\/jats:sec>","DOI":"10.1111\/sltb.12471","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T06:54:00Z","timestamp":1526280840000},"page":"899-913","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Neural Correlates of Suicidality in Adolescents with Major Depression: Resting\u2010State Functional Connectivity of the Precuneus and\u00a0Posterior Cingulate Cortex"],"prefix":"10.1111","volume":"49","author":[{"given":"Melinda Westlund","family":"Schreiner","sequence":"first","affiliation":[{"name":"Department of Psychology University of Minnesota College of Liberal Arts Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie","family":"Klimes\u2010Dougan","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Minnesota College of Liberal Arts Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn R.","family":"Cullen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Minnesota Medical School Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_6_3_1","volume-title":"Manual for the Beck Depression Inventory\u2010II","author":"Beck A. 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