{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:36:32Z","timestamp":1789940192073,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T00:00:00Z","timestamp":1363305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>We investigated the effect of hypoxic acclimatization <jats:italic>per se<\/jats:italic>, without any concomitant influence of strenuous physical activity on muscle and cerebral oxygenation. Eight healthy male subjects participated in a crossover\u2010designed study. In random order, they conducted a 10\u2010day normoxic (<jats:styled-content style=\"fixed-case\">CON<\/jats:styled-content>) and a 10\u2010day hypoxic (<jats:styled-content style=\"fixed-case\">EXP<\/jats:styled-content>) confinement. Pre and post both <jats:styled-content style=\"fixed-case\">CON<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">EXP<\/jats:styled-content> confinements, subjects conducted two incremental\u2010load cycling exercises to exhaustion; one under normoxic, and the other under hypoxic (<jats:styled-content style=\"fixed-case\"><jats:italic>F<\/jats:italic><jats:sub>I<\/jats:sub>O<\/jats:styled-content><jats:sub>2<\/jats:sub>\u2009=\u20090.154) conditions. Oxygen uptake (<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/sms12067-math-5001.png\" xlink:title=\"urn:x-wiley:09057188:media:sms12067:sms12067-math-5001\"\/>), ventilation (<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/sms12067-math-5002.png\" xlink:title=\"urn:x-wiley:09057188:media:sms12067:sms12067-math-5002\"\/>), and relative changes in regional hemoglobin oxygenation (\u0394([<jats:styled-content style=\"fixed-case\">HbO<jats:sub>2<\/jats:sub><\/jats:styled-content>]) in the cerebral cortex and in the serratus anterior (<jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content>) and vastus lateralis (<jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content>) muscles were measured. No changes were observed in the <jats:styled-content style=\"fixed-case\">CON<\/jats:styled-content> confinement. Peak work rate and <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/sms12067-math-5003.png\" xlink:title=\"urn:x-wiley:09057188:media:sms12067:sms12067-math-5003\"\/> were similar pre and post in the <jats:styled-content style=\"fixed-case\">EXP<\/jats:styled-content> confinement, whereas <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/sms12067-math-5004.png\" xlink:title=\"urn:x-wiley:09057188:media:sms12067:sms12067-math-5004\"\/> increased in the <jats:styled-content style=\"fixed-case\">EXP<\/jats:styled-content> post normoxic and hypoxic trials (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The exercise\u2010induced drop in <jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content> \u0394[<jats:styled-content style=\"fixed-case\">HbO<jats:sub>2<\/jats:sub><\/jats:styled-content>] was less in the post\u2010 than pre\u2010<jats:styled-content style=\"fixed-case\">EXP<\/jats:styled-content> trial by 4.0\u2009\u00b1\u20090.4 and 4.2\u2009\u00b1\u20090.6\u2009<jats:styled-content style=\"fixed-case\">\u03bcM<\/jats:styled-content> during normoxic and hypoxic exercise, respectively. No major changes were observed in cerebral or <jats:styled-content style=\"fixed-case\">SA<\/jats:styled-content> oxygenation. These results demonstrate that a 10\u2010day hypoxic exposure without any concomitant physical activity had no effect on normoxic or hypoxic <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/sms12067-math-5005.png\" xlink:title=\"urn:x-wiley:09057188:media:sms12067:sms12067-math-5005\"\/>, despite the enhanced <jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content> oxygenation.<\/jats:p>","DOI":"10.1111\/sms.12067","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T17:50:00Z","timestamp":1363369800000},"source":"Crossref","is-referenced-by-count":8,"title":["Peak oxygen uptake and regional oxygenation in response to a 10\u2010day confinement to normobaric hypoxia"],"prefix":"10.1111","volume":"23","author":[{"given":"S. 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E.","family":"Keramidas","sequence":"additional","affiliation":[{"name":"Department of Automation, Biocybernetics and Robotics Jozef Stefan Institute  Ljubljana Slovenia"},{"name":"Department of Environmental Physiology School of Technology and Health Royal Institute of Technology  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Eiken","sequence":"additional","affiliation":[{"name":"Department of Environmental Physiology School of Technology and Health Royal Institute of Technology  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Jaki Mekjavic","sequence":"additional","affiliation":[{"name":"Eye Hospital University Clinical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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