{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:28:53Z","timestamp":1789997333319,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2009\/12572"],"award-info":[{"award-number":["2009\/12572"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>This study investigated the effect of the dihydropyridine calcium channel antagonist, amlodipine, on blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) during resistance exercise performed at different intensities in hypertensives. Eleven hypertensives underwent 4 weeks of placebo and amlodipine (random double\u2010blinded crossover design). In each phase, they performed knee extension exercise until exhaustion following three protocols: one set at 100% of <jats:styled-content style=\"fixed-case\">1 RM<\/jats:styled-content> (repetition maximum), three sets at 80% of <jats:styled-content style=\"fixed-case\">1 RM<\/jats:styled-content>, and three sets at 40% of <jats:styled-content style=\"fixed-case\">1 RM<\/jats:styled-content>. Intraarterial <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> was measured before and during exercise. Amlodipine reduced maximal systolic\/diastolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> values achieved at all intensities (100%\u2009=\u2009225\u2009\u00b1\u20096\/141\u2009\u00b1\u20093 vs. 207\u2009\u00b1\u20096\/130\u2009\u00b1\u20096\u2009mmHg; 80%\u2009=\u2009289\u2009\u00b1\u20098\/178\u2009\u00b1\u20095 vs. 273\u2009\u00b1\u200910\/169\u2009\u00b1\u20096\u2009mmHg; 40%\u2009=\u2009289\u2009\u00b1\u200910\/176\u2009\u00b1\u20098 vs. 271\u2009\u00b1\u200911\/154\u2009\u00b1\u20096\u2009mmHg). Amlodipine blunted the increase in diastolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> that occurred during the second and third sets of exercise at 40% of <jats:styled-content style=\"fixed-case\">1RM<\/jats:styled-content> (+75\u2009\u00b1\u20096 vs. +61\u2009\u00b1\u20095\u2009mmHg and +78\u2009\u00b1\u20097 vs. +64\u2009\u00b1\u20095\u2009mmHg, respectively). Amlodipine was effective in reducing the absolute values of systolic and diastolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> during resistance exercise and in preventing the progressive increase in diastolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> that occurs over sets of low\u2010intensity exercise. These results suggest that systemic vascular resistance is involved in <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> increase during resistance exercise, and imply that hypertensives receiving amlodipine are at lower risk of increased <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> during resistance exercise than non\u2010medicated patients.<\/jats:p>","DOI":"10.1111\/sms.12152","type":"journal-article","created":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T06:37:43Z","timestamp":1385015863000},"page":"53-60","source":"Crossref","is-referenced-by-count":7,"title":["Amlodipine reduces blood pressure during dynamic resistance exercise in hypertensive patients"],"prefix":"10.1111","volume":"25","author":[{"given":"D. R.","family":"Souza","sequence":"first","affiliation":[{"name":"Exercise Hemodynamic Laboratory, School of Physical Education and Sport University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. S.","family":"Gomides","sequence":"additional","affiliation":[{"name":"Exercise Hemodynamic Laboratory, School of Physical Education and Sport University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A. R.","family":"Costa","sequence":"additional","affiliation":[{"name":"Exercise Hemodynamic Laboratory, School of Physical Education and Sport University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C. C.","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Exercise Hemodynamic Laboratory, School of Physical Education and Sport University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Barros","sequence":"additional","affiliation":[{"name":"Hypertension Unit, General Hospital University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. C.","family":"Ortega","sequence":"additional","affiliation":[{"name":"Hypertension Unit, General Hospital University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"D.","family":"Mion","sequence":"additional","affiliation":[{"name":"Hypertension Unit, General Hospital University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Tinucci","sequence":"additional","affiliation":[{"name":"Exercise Hemodynamic Laboratory, School of Physical Education and Sport University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Hypertension Unit, General Hospital University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. L. 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