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This study aimed to identify whether this could be related to selected humoral or intramuscular inflammatory factors. Twenty\u2010three subjects were divided into non\u2010exercising (<jats:italic>n<\/jats:italic>\u2009=\u20095) and downhill run (<jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>; <jats:italic>n<\/jats:italic>\u2009=\u200918) groups (12\u2009\u00d7\u20095\u2009min, 10% decline at 15\u2009km\/h). Blood samples were analyzed for white blood cell differential count, <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content>, myoglobin, tumor necrosis factor\u2010\u03b1, granulocyte colony\u2010stimulating factor, interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20101\u03b2, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010. Muscle biopsies were analyzed for signal transducer and activator of transcription\u20103 (<jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3), <jats:styled-content style=\"fixed-case\">I\u03baB\u03b1<\/jats:styled-content>, and myeloperoxidase (<jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content> participants clustered as early (<jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>1) recovery, biphasic response (<jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>2), or classic delayed exaggerated <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content> response (<jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>3), with a delayed <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content> peak (4784\u2009\u00b1\u20091496\u2009U\/L) on day 4. For <jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>2, <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content> peaked on day 1 (<jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>1: 1198\u2009\u00b1\u2009837\u2009U\/L) or on day 1 and day 4 (<jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>2: 1583\u2009\u00b1\u2009448\u2009U\/L; 1878\u2009\u00b1\u2009427\u2009U\/L), respectively. Immediately post\u2010<jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 increased in <jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>2 and <jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>3 whereas <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 increased in all <jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content> groups. <jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3 signaling increased for <jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>2 at 4\u2009h, but <jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content> at day 2 only in <jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>2. Objective cluster analysis uncovered a group of subjects with a characteristic biphasic <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content> release after <jats:styled-content style=\"fixed-case\">DHR<\/jats:styled-content>. The second elevation was related to their early cytokine response. The results provide evidence that early responses following eccentric exercise are indicative of later variation.<\/jats:p>","DOI":"10.1111\/sms.12164","type":"journal-article","created":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T06:40:44Z","timestamp":1388731244000},"source":"Crossref","is-referenced-by-count":11,"title":["Variable inflammation and intramuscular <scp>STAT<\/scp>3 phosphorylation and myeloperoxidase levels after downhill running"],"prefix":"10.1111","volume":"24","author":[{"given":"M.","family":"van de Vyver","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences Stellenbosch University  Stellenbosch South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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