{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:22:28Z","timestamp":1770834148577,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,8,24]],"date-time":"2014-08-24T00:00:00Z","timestamp":1408838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"S\u00ef\u00bf\u00bdo Paulo Research Foundation (FAPESP)","award":["2009\/54420-5 and 09\/53904-9"],"award-info":[{"award-number":["2009\/54420-5 and 09\/53904-9"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2015,6]]},"abstract":"The aim of this study was to investigate if the aerobic training (AT<\/jats:styled-content>) reverses airway remodeling (AR<\/jats:styled-content>) in an asthma model. BALB<\/jats:styled-content>\/c were divided into four groups: control (unsensitized and untrained); ovalbumin (OVA<\/jats:styled-content>: sensitized and untrained); AT<\/jats:styled-content> (unsensitized and trained) and OVA<\/jats:styled-content>\u2009+\u2009AT<\/jats:styled-content>. Allergic inflammation was induced with intraperitoneal and OVA<\/jats:styled-content> inhalation. AT<\/jats:styled-content> (low intensity; 5\u00d7\/week; 60\u2009min\/session) was performed at 7, 15, and 30 days. Leukocyte counting in the bronchoalveolar lavage fluid; the expression of IL<\/jats:styled-content>\u20105, eotaxin, RANTES<\/jats:styled-content>, intercellular adhesion molecule\u20101 (ICAM<\/jats:styled-content>\u20101), vascular cell adhesion molecule\u20101 (VCAM<\/jats:styled-content>\u20101); AR<\/jats:styled-content> features (airway smooth muscle, epithelium thickness, collagen and elastic fibers, mucus production); and AR<\/jats:styled-content> inducers (transforming growing factor\u2010beta, osteopontin, vascular endothelial growth factor). OVA<\/jats:styled-content> induced an increase in leukocyte airway migration and increased AR<\/jats:styled-content> features (P<\/jats:italic>\u2009<\u20090.05). After 7 days, AT<\/jats:styled-content> reversed the OVA<\/jats:styled-content>\u2010induced eosinophil and macrophage airway migration, the expression of IL<\/jats:styled-content>\u20105, eotaxin, RANTES<\/jats:styled-content>, ICAM<\/jats:styled-content>\u20101, VCAM<\/jats:styled-content>\u20101, and all AR<\/jats:styled-content> inducers. However, total reversion of the AR<\/jats:styled-content> features and inducers and airway inflammation occurred only after 15 days of AT<\/jats:styled-content> compared with the OVA<\/jats:styled-content> groups (P<\/jats:italic>\u2009<\u20090.05) and the effects were maintained until the 30th day. AT<\/jats:styled-content> reverses AR<\/jats:styled-content> after 15 days and this effect is preceded by the inhibition of leukocyte migration and occurs simultaneously with the reduction in the expression of inflammatory mediators and AR<\/jats:styled-content> inducers.<\/jats:p>","DOI":"10.1111\/sms.12311","type":"journal-article","created":{"date-parts":[[2014,8,25]],"date-time":"2014-08-25T02:01:00Z","timestamp":1408932060000},"source":"Crossref","is-referenced-by-count":14,"title":["Airway remodeling is reversed by aerobic training in a murine model of chronic asthma"],"prefix":"10.1111","volume":"25","author":[{"given":"R. A.","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Physical Therapy School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Department of Clinical Medicine (LIM\u201020) School of Medicine University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. 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