{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:31:10Z","timestamp":1791153070944,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T00:00:00Z","timestamp":1421798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008368","name":"Gigtforeningen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008368","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>\n                    This study investigated the hypertrophic potential of load\u2010matched blood\u2010flow restricted resistance training (\n                    <jats:styled-content style=\"fixed-case\">BFR<\/jats:styled-content>\n                    ) vs free\u2010flow traditional resistance training (low\u2010load\n                    <jats:styled-content style=\"fixed-case\">TRT<\/jats:styled-content>\n                    ) performed to fatigue. Ten healthy young subjects performed unilateral\n                    <jats:styled-content style=\"fixed-case\">BFR<\/jats:styled-content>\n                    and contralateral low\u2010load\n                    <jats:styled-content style=\"fixed-case\">TRT<\/jats:styled-content>\n                    elbow flexor dumbbell curl with 40% of one repetition maximum until volitional concentric failure 3 days per week for 6 weeks. Prior to and at 3 (post\u20103) and 10 (post\u201010) days post\u2010training, magnetic resonance imaging (\n                    <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                    ) was used to estimate elbow flexor muscle volume and muscle water content accumulation through training. Acute changes in muscle thickness following an early vs a late exercise bout were measured with ultrasound to determine muscle swelling during the immediate 0\u201348\u2009h post\u2010exercise. Total work was threefold lower for\n                    <jats:styled-content style=\"fixed-case\">BFR<\/jats:styled-content>\n                    compared with low\u2010load\n                    <jats:styled-content style=\"fixed-case\">TRT<\/jats:styled-content>\n                    (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001). Both\n                    <jats:styled-content style=\"fixed-case\">BRF<\/jats:styled-content>\n                    and low\u2010load\n                    <jats:styled-content style=\"fixed-case\">TRT<\/jats:styled-content>\n                    increased muscle volume by approximately 12% at post\u20103 and post\u201010 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.01) with no changes in\n                    <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                    \u2010determined water content. Training increased muscle thickness during the immediate 48\u2009h post\u2010exercise (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.001) and to greater extent with\n                    <jats:styled-content style=\"fixed-case\">BRF<\/jats:styled-content>\n                    (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u20090.05) in the early training phase. In conclusion,\n                    <jats:styled-content style=\"fixed-case\">BFR<\/jats:styled-content>\n                    and low\u2010load\n                    <jats:styled-content style=\"fixed-case\">TRT<\/jats:styled-content>\n                    , when performed to fatigue, produce equal muscle hypertrophy, which may partly rely on transient exercise\u2010induced increases in muscle water content.\n                  <\/jats:p>","DOI":"10.1111\/sms.12396","type":"journal-article","created":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T07:37:01Z","timestamp":1421825821000},"page":"754-763","source":"Crossref","is-referenced-by-count":164,"title":["Blood flow restricted and traditional resistance training performed to fatigue produce equal muscle hypertrophy"],"prefix":"10.1111","volume":"25","author":[{"given":"J.","family":"Farup","sequence":"first","affiliation":[{"name":"Section for Sport Science Department of Public Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"de Paoli","sequence":"additional","affiliation":[{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Bjerg","sequence":"additional","affiliation":[{"name":"Section for Sport Science Department of Public Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Riis","sequence":"additional","affiliation":[{"name":"Section for Sport Science Department of Public Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ringgard","sequence":"additional","affiliation":[{"name":"MR\u2010Research Centre Department of Clinical Medicine Aarhus University Hospital  Aarhus 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