{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:52:48Z","timestamp":1792079568840,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T00:00:00Z","timestamp":1424217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2015,12]]},"abstract":"\n The purpose of this investigation was to evaluate differences in quadriceps corticospinal excitability, spinal\u2010reflexive excitability, strength, and voluntary activation before, 2 weeks post and 6 months post\u2010anterior cruciate ligament reconstruction (\n ACLr<\/jats:styled-content>\n ). This longitudinal, case\u2010control investigation examined 20 patients scheduled for\n ACLr<\/jats:styled-content>\n (11 females, 9 males; age: 20.9\u2009\u00b1\u20094.4\u2009years; height:172.4\u2009\u00b1\u20097.5\u2009cm; weight:76.2\u2009\u00b1\u200911.8\u2009kg) and 20 healthy controls (11 females, 9 males; age:21.7\u2009\u00b1\u20093.7 years; height: 173.7\u2009\u00b1\u20099.9\u2009cm; weight: 76.1\u2009\u00b1\u200919.7\u2009kg). Maximal voluntary isometric contractions (\n MVIC<\/jats:styled-content>\n ), central activation ratio (\n CAR<\/jats:styled-content>\n ), normalized\n H<\/jats:styled-content>\n offmann spinal reflexes, active motor threshold (\n AMT<\/jats:styled-content>\n ), and normalized motor\u2010evoked potential (\n MEP<\/jats:styled-content>\n ) amplitudes at 120% of\n AMT<\/jats:styled-content>\n were measured in the quadriceps muscle at the specific time points.\n ACLr<\/jats:styled-content>\n patients demonstrated bilateral reductions in spinal\u2010reflexive excitability compared with controls before surgery (\n P<\/jats:italic>\n \u2009=\u20090.02) and 2 weeks post\u2010surgery (\n P<\/jats:italic>\n \u2009\u2264\u20090.001).\n ACLr<\/jats:styled-content>\n patients demonstrated higher\n AMT<\/jats:styled-content>\n at 6 months post\u2010surgery (\n P<\/jats:italic>\n \u2009\u2264\u20090.001) in both limbs. No\n MEP<\/jats:styled-content>\n differences were detected. Quadriceps\n MVIC<\/jats:styled-content>\n and\n CAR<\/jats:styled-content>\n were lower in both limbs of the\n ACLr<\/jats:styled-content>\n group before surgery and 6 months post\u2010surgery (\n P<\/jats:italic>\n \u2009\u2264\u20090.05) compared with controls. Diminished excitability of spinal\u2010reflexive and corticospinal pathways are present at different times following\n ACLr<\/jats:styled-content>\n and occur in combination with clinical deficits in quadriceps strength and activation. Early rehabilitation strategies targeting spinal\u2010reflexive excitability may help improve postoperative outcomes, while later\u2010stage rehabilitation may benefit from therapeutic techniques aimed at improving corticospinal excitability.\n <\/jats:p>","DOI":"10.1111\/sms.12435","type":"journal-article","created":{"date-parts":[[2015,2,18]],"date-time":"2015-02-18T22:32:55Z","timestamp":1424298775000},"page":"828-839","source":"Crossref","is-referenced-by-count":219,"title":["Quadriceps neural alterations in anterior cruciate ligament reconstructed patients: A 6\u2010month longitudinal investigation"],"prefix":"10.1111","volume":"25","author":[{"given":"A. S.","family":"Lepley","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Health Promotion University of Kentucky Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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