{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:22:36Z","timestamp":1770744156478,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T00:00:00Z","timestamp":1434499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>This study investigated features of skeletal muscle ageing in elderly individuals having previously undergone unilateral total knee arthroplasty (<jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content>) and whether markers of sarcopenia could be mitigated by a 12\u2010week alpine skiing intervention. Novel biomarkers agrin, indicative of neuromuscular junction (<jats:styled-content style=\"fixed-case\">NMJ<\/jats:styled-content>) degeneration, tumor suppressor protein p53, associated with muscle atrophy, and a new ultrasound\u2010based muscle architecture biomarker were used to characterize sarcopenia. Participant details and study design are presented by <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>\u00f6sters et\u2009al. (2015). The results of this study show that <jats:styled-content style=\"fixed-case\">NMJ<\/jats:styled-content> degeneration is widespread among active septuagenarians previously subjected to <jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content>: all participants showed elevated agrin levels upon recruitment. At least 50% of individuals were identified as sarcopenic based on their muscle architecture, supporting the hypothesis that <jats:styled-content style=\"fixed-case\">NMJ<\/jats:styled-content> alterations precede sarcopenia. Notably, sarcopenia was strongly associated with the expression of p53, which seems to confirm its validity as a biomarker of muscle atrophy. Training did not significantly modify any of these biomarkers. In view of the lack of accretion of muscle mass in response to the alpine skiing intervention, we hypothesize that local muscle inflammation and oxidative stress may have blunted the anabolic response to training and promoted muscle breakdown in this elderly post\u2010<jats:styled-content style=\"fixed-case\">TKA<\/jats:styled-content> population.<\/jats:p>","DOI":"10.1111\/sms.12458","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T11:25:10Z","timestamp":1434540310000},"page":"33-39","source":"Crossref","is-referenced-by-count":7,"title":["Alpine Skiing With total knee ArthroPlasty (ASWAP): impact on molecular and architectural features of musculo\u2010skeletal ageing"],"prefix":"10.1111","volume":"25","author":[{"given":"M.","family":"Narici","sequence":"first","affiliation":[{"name":"MRC ARUK Centre for Musculoskeletal Ageing Research Faculty of Medicine University of Nottingham  Nottingham 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