{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:15:14Z","timestamp":1788232514053,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,8,17]],"date-time":"2015-08-17T00:00:00Z","timestamp":1439769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Vice-Rectorate of Research and Science"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>\n                    The aim of this investigation was to determine the influence of\n                    <jats:styled-content style=\"fixed-case\">CFTR<\/jats:styled-content>\n                    genotype on body water and electrolyte balance during a marathon. Fifty\u2010one experienced runners completed a marathon race. Before and after the race, body mass and a sample of venous blood were obtained. During the race, sweat samples were collected using sweat patches, and fluid and electrolyte intake were obtained using self\u2010reported questionnaires. Thirty\u2010eight participants (74.5% of the total) were 7T\/7T homozygotes, 11 (21.6%) were 7T\/9T heterozygotes, and one participant presented the rare genotype 5T\/7T. Another participant with 9T\/9T presented the mutation p.L206W. Participants with 7T\/7T showed higher sweat sodium concentrations (42.2\u2009\u00b1\u200921.6\u2009mmol\/L) than 7T\/9T (29.0\u2009\u00b1\u200924.7\u2009mmol\/L;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.04). The runner with the 5T\/7T genotype (10.2\u2009mmol\/L) and the participant with the p.L206W mutation (20.5\u2009mmol\/L) exhibited low\u2010range sweat sodium concentrations. However, post\u2010race serum sodium concentration was similar in 7T\/7T and 7T\/9T (142.1\u2009\u00b1\u20091.3 and 142.4\u2009\u00b1\u20091.6\u2009mmol\/L, respectively;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.27) and did not show abnormalities in participants with the 5T\/7T genotype (140.0\u2009mmol\/L) and the p.L206W mutation (143.0\u2009mmol\/L). Runners with the\n                    <jats:styled-content style=\"fixed-case\">CFTR<\/jats:styled-content>\n                    \u20107T\/7T genotype exhibited increased sweat sodium concentrations during a marathon. However, this phenotype was not related with increased likelihood of suffering body water and electrolyte imbalances during real competitions.\n                  <\/jats:p>","DOI":"10.1111\/sms.12542","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T00:03:27Z","timestamp":1439856207000},"page":"1036-1044","source":"Crossref","is-referenced-by-count":8,"title":["<scp>CFTR<\/scp>\n                    genotype\u2010related body water and electrolyte balance during a marathon"],"prefix":"10.1111","volume":"26","author":[{"given":"J.","family":"Del Coso","sequence":"first","affiliation":[{"name":"Exercise Physiology Laboratory Camilo Jos\u00e9 Cela University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Lara","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory Camilo Jos\u00e9 Cela University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-5100","authenticated-orcid":false,"given":"J. J.","family":"Salinero","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory Camilo Jos\u00e9 Cela University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Areces","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory Camilo Jos\u00e9 Cela University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ruiz\u2010Vicente","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory Camilo Jos\u00e9 Cela University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gallo\u2010Salazar","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory Camilo Jos\u00e9 Cela University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Abi\u00e1n\u2010Vic\u00e9n","sequence":"additional","affiliation":[{"name":"Exercise Physiology Laboratory Camilo Jos\u00e9 Cela University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cacabelos","sequence":"additional","affiliation":[{"name":"Chair of Genomic Medicine Camilo Jos\u00e9 Cela University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2002.620108.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.zdg-8179.vpcomm.2008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wem.2014.08.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00660.2010"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00551.2010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20156"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1139\/H07-188"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1977.tb38195.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020531"},{"key":"e_1_2_9_11_1","unstructured":"Cystic Fibrosis Centre at the Hospital for Sick Children in Toronto.Cystic fibrosis mutation database.2014http:\/\/www.genet.sickkids.on.ca\/. Accesed by 1 July 2014."},{"key":"e_1_2_9_12_1","article-title":"Effects of oral salt supplementation on physical performance during a half\u2010ironman: a randomized controlled trial","author":"Del Coso J","year":"2015","journal-title":"Scand J Med Sci Sports"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1974.37.2.247"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00218824"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1249\/JSR.0b013e31817f3b35"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9183"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4085\/1062-6050-45.4.364"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-011-1911-6"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1234056"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e3182a35dbd"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.2005.018481"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003677-200107000-00005"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-010-0930-4"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509096102"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2009.03.001"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(89)70063-3"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e31802ca597"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/02640410701607353"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00924.2007"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/JES.0b013e3182172a5a"}],"container-title":["Scandinavian Journal of Medicine &amp; Science in Sports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsms.12542","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sms.12542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T22:35:38Z","timestamp":1696199738000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sms.12542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,17]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/sms.12542"],"URL":"https:\/\/doi.org\/10.1111\/sms.12542","archive":["Portico"],"relation":{},"ISSN":["0905-7188","1600-0838"],"issn-type":[{"value":"0905-7188","type":"print"},{"value":"1600-0838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,17]]}}}