{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:19:03Z","timestamp":1789733943248,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T00:00:00Z","timestamp":1471564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>Health care decision\u2010making requires evidence of the cost\u2010effectiveness of medical therapies. We evaluated the cost\u2010effectiveness of exercise\u2010based cardiac rehabilitation (<jats:styled-content style=\"fixed-case\">ECR<\/jats:styled-content>) implemented according to guidelines. All the patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0204) had experienced a recent acute coronary syndrome and were randomized to a 1\u2010year <jats:styled-content style=\"fixed-case\">ECR<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a0109) or usual care (<jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>) group (<jats:italic>n<\/jats:italic>\u00a0=\u00a095). The patients\u2019 health\u2010related quality of life was followed using the 15D instrument and health care costs were collected from electronic health registries. The cost\u2010effectiveness of <jats:styled-content style=\"fixed-case\">ECR<\/jats:styled-content> was estimated based on intervention and health care costs and quality\u2010adjusted life years (<jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>s) gained. The total average cost per patient was lower in <jats:styled-content style=\"fixed-case\">ECR<\/jats:styled-content> than in <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>. The incremental cost was divided by the baseline\u2010adjusted incremental <jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>s (0.045), yielding an incremental cost\u2010effectiveness ratio of \u2212\u20ac24511\/<jats:styled-content style=\"fixed-case\">QALY<\/jats:styled-content>s. A combined endpoint of mortality, recurrent coronary event, or hospitalization for a heart failure occurred for five patients in <jats:styled-content style=\"fixed-case\">ECR<\/jats:styled-content> and 16 patients in <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 3.9, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.4\u201310.6, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004, relative risk reduction 73%, number needed to treat eight). <jats:styled-content style=\"fixed-case\">ECR<\/jats:styled-content> is a dominant treatment option and decreases the occurrence of adverse cardiac events. These results are useful for decision\u2010making when planning optimal utilization of resources in Finnish health care.<\/jats:p>","DOI":"10.1111\/sms.12738","type":"journal-article","created":{"date-parts":[[2016,8,19]],"date-time":"2016-08-19T13:34:07Z","timestamp":1471613647000},"page":"1395-1403","source":"Crossref","is-referenced-by-count":36,"title":["Economic evaluation of exercise\u2010based cardiac rehabilitation in patients with a recent acute coronary syndrome"],"prefix":"10.1111","volume":"27","author":[{"given":"A. J.","family":"Hautala","sequence":"first","affiliation":[{"name":"Center for Machine Vision and Signal Analysis Faculty of Information Technology and Electrical Engineering University of Oulu Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Kiviniemi","sequence":"additional","affiliation":[{"name":"Medical Research Center Oulu Oulu University Hospital and University of Oulu Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"M\u00e4kikallio","sequence":"additional","affiliation":[{"name":"Medical Research Center Oulu Oulu University Hospital and University of Oulu Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Koistinen","sequence":"additional","affiliation":[{"name":"Social and Health Services City of Oulu Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.\u2010P.","family":"Ryyn\u00e4nen","sequence":"additional","affiliation":[{"name":"Kuopio University Hospital University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Martikainen","sequence":"additional","affiliation":[{"name":"Pharmacoeconomics &amp; Outcomes Research Unit School of Pharmacy University of Eastern Finland Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sepp\u00e4nen","sequence":"additional","affiliation":[{"name":"Center for Machine Vision and Signal Analysis Faculty of Information Technology and Electrical Engineering University of Oulu Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. V.","family":"Huikuri","sequence":"additional","affiliation":[{"name":"Medical Research Center Oulu Oulu University Hospital and University of Oulu Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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