{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T22:08:42Z","timestamp":1782425322110,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Interdisciplinary Research Funding Program (intramural) of the National Center for Tumor Diseases (NCT)","award":["IFP project VI.1"],"award-info":[{"award-number":["IFP project VI.1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p>Exercise is considered to be an effective supportive treatment approach in breast cancer (<jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content>) patients. We conducted a randomized controlled trial to assess the efficacy of a 12\u2010week <jats:styled-content style=\"fixed-case\">PRT<\/jats:styled-content> during radiotherapy. Strength performance was assessed by maximal isokinetic peak torque (<jats:styled-content style=\"fixed-case\">MIPT<\/jats:styled-content>) in two different angular velocities (60\u00b0\/s and 180\u00b0\/s) and maximal voluntary isometric contraction for shoulder external and internal rotation, as well as for knee extension and flexion were assessed pre\u2010 and post\u2010intervention in 146 patients randomized to <jats:styled-content style=\"fixed-case\">PRT<\/jats:styled-content> or a control group. Statistical analyses were based on analysis of covariance models for the individual changes from baseline to week 13. Intention\u2010to\u2010treat analyses showed significant between\u2010group differences favoring the exercise group (<jats:styled-content style=\"fixed-case\">EX<\/jats:styled-content>) for <jats:styled-content style=\"fixed-case\">MIPT<\/jats:styled-content> in knee flexion and shoulder internal and external rotation (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05). Subgroup analyses showed borderline significant differences with regard to pretreatment history, revealing that pretreated chemotherapy patients tend to benefit more from <jats:styled-content style=\"fixed-case\">PRT<\/jats:styled-content> than patients without chemotherapy (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.06). Strength gain at the operated arm was significantly higher than at the non\u2010operated arm in <jats:styled-content style=\"fixed-case\">EX<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">PRT<\/jats:styled-content> was efficacious in increasing upper and lower limb strength in <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content> patients undergoing adjuvant radiotherapy. Patients with restrictions due to breast cancer\u2010related surgery and pretreated with chemotherapy might benefit the most.<\/jats:p>","DOI":"10.1111\/sms.12777","type":"journal-article","created":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T16:39:48Z","timestamp":1476290388000},"page":"1500-1510","source":"Crossref","is-referenced-by-count":37,"title":["Effects of 12\u2010week resistance training during radiotherapy in breast cancer patients"],"prefix":"10.1111","volume":"27","author":[{"given":"J.","family":"Wiskemann","sequence":"first","affiliation":[{"name":"Division of Medical Oncology National Center for Tumor Diseases and Heidelberg University Hospital Heidelberg Germany"},{"name":"Division of Preventive Oncology National Center for Tumor Diseases and German Cancer Research Center Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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