{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:30:54Z","timestamp":1761823854111},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T00:00:00Z","timestamp":1482883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health and Medical Research Council of Australia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Tendinopathy is a common condition, which has been linked to surrogate measures of sympathetic nervous system (<jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content>) activity and insulin resistance. This study aimed to compare in vivo measures of the <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> and insulin resistance between individuals with and without Achilles tendinopathy. This case\u2013control study compared Achilles tendinopathy sufferers to healthy controls. <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> activity was quantified using muscle sympathetic nerve activity (<jats:styled-content style=\"fixed-case\">MSNA<\/jats:styled-content>), while metabolic status was assessed via a modified glucose tolerance test and fasting lipid panel. Ultrasound tissue characterization assessed tendon structure. Resting <jats:styled-content style=\"fixed-case\">MSNA<\/jats:styled-content> did not differ between the 15 cases and 20 controls. Tendon pain duration in tendinopathy patients was correlated with burst frequency (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>=.32, <jats:italic>P<\/jats:italic>=.02) and burst incidence (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>=.41, <jats:italic>P<\/jats:italic>=.01) of <jats:styled-content style=\"fixed-case\">MSNA<\/jats:styled-content>. After adjusting for multiple comparisons, there was a trend suggesting fasting glucose was greater in cases (median 4.80, <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> .70 in cases vs 4.51, .38 in controls) and correlated with pain severity (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>=.14, <jats:italic>P<\/jats:italic>=.03), but no other metabolic measures were associated with tendon pain\/structure. This study indicates that <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> activity is associated with tendon pain duration, building on previous data indicating the <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> is involved in recalcitrant tendinopathy. Metabolic parameters had little relationship with Achilles tendinopathy in this metabolically homogenous sample. Prospective studies are required to uncover the precise relationship between <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> activity, insulin resistance, and tendinopathy.<\/jats:p>","DOI":"10.1111\/sms.12820","type":"journal-article","created":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T09:36:21Z","timestamp":1482917781000},"page":"1942-1949","source":"Crossref","is-referenced-by-count":7,"title":["Pain duration is associated with increased muscle sympathetic nerve activity in patients with Achilles tendinopathy"],"prefix":"10.1111","volume":"27","author":[{"given":"J. L.","family":"Jewson","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Nursing and Health Sciences Monash University  Melbourne Vic. Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. A.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Human Neurotransmitters Laboratory Baker IDI Heart and Diabetes Institute  Melbourne Vic. 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