{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:00:14Z","timestamp":1791140414372,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T00:00:00Z","timestamp":1491955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"German Federal Ministry of Education and Research","award":["BMBF FKZ 01ET0713"],"award-info":[{"award-number":["BMBF FKZ 01ET0713"]}]},{"DOI":"10.13039\/501100013295","name":"Helmholtz Zentrum M\u00fcnchen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100013295","id-type":"DOI","asserted-by":"crossref"}]},{"name":"German Research Center for Environmental Health, Neuherberg"},{"DOI":"10.13039\/501100010571","name":"Federal Ministry of Education, Science, Research and Technology","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010571","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2018,2]]},"abstract":"The purpose of this study was to examine whether physical activity (PA<\/jats:styled-content>) and muscular strength (MS<\/jats:styled-content>) are related to polypharmacy. Our cross\u2010sectional analysis was based on 711 patients with multimorbidity (MMB<\/jats:styled-content>), aged 65\u201094\u00a0years, who participated in the KORA<\/jats:styled-content>\u2010Age study. Participants underwent a face\u2010to\u2010face interview and extensive physical examinations including anthropometric measurements, registration of chronic diseases, determination of health\u2010related behaviors (smoking, alcohol intake, physical activity, etc.), collection of blood samples and measurement of hand\u2010grip strength. PP<\/jats:styled-content>ha was defined as the use of >4 drugs and MMB<\/jats:styled-content> as having \u22652 of 13 chronic diseases. Prevalence of PP<\/jats:styled-content>ha was 44.6% (n=317), and a significant difference was found in the number of drugs used between participants with and without PP<\/jats:styled-content>ha (7.2\u00b12.1 vs 2.5\u00b11.2, P<\/jats:italic><.001). Patients in the lower compared to the upper tertile of physical activity had a significantly increased odds to be on PP<\/jats:styled-content>ha (OR<\/jats:styled-content>: 1.64, 95% CI<\/jats:styled-content>: 1.05\u20102.56, P<\/jats:italic>=.031) after controlling for age, gender, BMI<\/jats:styled-content>, family status, education, alcohol intake, smoking habits, number of diseases, hs\u2010CRP<\/jats:styled-content>, and telomere length. On the contrary, no significant association between muscular strength and PP<\/jats:styled-content>ha was found (OR<\/jats:styled-content>: 1.04, 95% CI<\/jats:styled-content>: 0.66\u20101.63, P<\/jats:italic>=.873) after multivariable adjustment. Among older persons with MMB<\/jats:styled-content>, lower levels of physical activity, but not low muscular strength, are associated with higher odds of PP<\/jats:styled-content>ha. Increasing the levels of physical activity appears to be highly recommended in order to potentially reduce the risk of PP<\/jats:styled-content>ha among multimorbid persons aged 65 and older.<\/jats:p>","DOI":"10.1111\/sms.12884","type":"journal-article","created":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T13:46:06Z","timestamp":1490276766000},"page":"604-612","source":"Crossref","is-referenced-by-count":27,"title":["Physical activity, muscular strength, and polypharmacy among older multimorbid persons: Results from the KORA<\/scp>\u2010Age study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6482-2199","authenticated-orcid":false,"given":"K. A.","family":"Volaklis","sequence":"first","affiliation":[{"name":"Department of Prevention and Sports Medicine Technische Universitaet Muenchen Munich Germany"},{"name":"7FIT Cardiac Rehabilitation Center Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Thorand","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology II Helmholtz Zentrum M\u00fcnchen German Research Center for Environmental Health Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Peters","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology II Helmholtz Zentrum M\u00fcnchen German Research Center for Environmental Health Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Halle","sequence":"additional","affiliation":[{"name":"Department of Prevention and Sports Medicine Technische Universitaet Muenchen Munich Germany"},{"name":"Else\u2010Kr\u00f6ner\u2010Fresenius\u2010Zentrum Munich Germany"},{"name":"DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Heier","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology II Helmholtz Zentrum M\u00fcnchen German Research Center for Environmental Health Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Strasser","sequence":"additional","affiliation":[{"name":"Division of Medical Biochemistry Biocenter Medical University Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Amann","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology II Helmholtz Zentrum M\u00fcnchen German Research Center for Environmental Health Neuherberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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