{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:33:28Z","timestamp":1791311608062,"version":"4.3.1"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006308","name":"Helga og Peter Kornings Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006308","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002739","name":"Aarhus Universitets Forskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Low\u2010load blood flow restricted resistance exercise (BFRE) performed to volitional failure is suggested to constitute an effective method for producing increases in muscle size and function. However, BFRE to failure may entail high levels of perceived exertion, discomfort, and\/or delayed onset of muscle soreness (DOMS). The aim of the study was to compare BFRE performed to volitional failure (F\u2010BFRE) vs non\u2010failure BFRE (NF\u2010BFRE) on changes in muscle size, function and perceptual responses. Fourteen young untrained males had one leg randomized to knee extension F\u2010BFRE while the contralateral leg performed NF\u2010BFRE. The training consisted of 22 exercise bouts over an 8\u2010week period. Whole\u2010muscle cross\u2010sectional area (CSA) of quadriceps components, muscle function, and DOMS were assessed before and after the training period. Perceived exertion and discomfort were registered during each exercise bout. Both F\u2010BFRE and NF\u2010BFRE produced regional increases in muscle CSA in the range of: quadriceps (2.5%\u20103.8%), vastus lateralis (8.1%\u20108.5%), and rectus femoris (7.9%\u201025.0%). All without differences between leg. Muscle strength (6.8%\u201011.5%) and strength\u2010endurance capacity (13.9%\u201018.6%) also increased to a similar degree in both legs. Less perceived exertion, discomfort, and DOMS were reported with NF\u2010BFRE compared to F\u2010BFRE. In conclusion, non\u2010failure BFRE enables increases in muscle size and muscle function, while involving reduced perceptions of exertion, discomfort, and DOMS. Non\u2010failure BFRE may be a more feasible approach in clinical settings.<\/jats:p>","DOI":"10.1111\/sms.13346","type":"journal-article","created":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T14:32:37Z","timestamp":1543242757000},"page":"336-347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Non\u2010failure blood flow restricted exercise induces similar muscle adaptations and less discomfort than failure protocols"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5074-9285","authenticated-orcid":false,"given":"Peter","family":"Sieljacks","sequence":"first","affiliation":[{"name":"Section for Sports Science, Department of Public Health Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rune","family":"Degn","sequence":"additional","affiliation":[{"name":"Section for Sports Science, Department of Public Health Aarhus 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