{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:19:00Z","timestamp":1788823140913,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T00:00:00Z","timestamp":1546732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:p>We examined the effect of curcumin (CUR) ingestion before or after exercise on changes in muscle damage and inflammatory responses after exercise. We conducted two parallel experiments with different CUR ingestion timings using a double\u2010blind crossover. In Exp. 1, ten healthy men ingested 180\u00a0mg\u00a0d<jats:sup>\u22121<\/jats:sup> of CUR or placebo (PLA) 7\u00a0days before exercise. In Exp. 2, ten other healthy men ingested 180\u00a0mg\u00a0d<jats:sup>\u22121<\/jats:sup> of CUR or PLA 7\u00a0days after exercise. They performed 30 maximal isokinetic (120\u00b0s<jats:sup>\u22121<\/jats:sup>) eccentric contractions of the elbow flexors using an isokinetic dynamometer, and this was repeated with the other arm \u22654\u00a0weeks later. Maximal voluntary contraction (MVC) torque of the elbow flexors, elbow joint range of motion (ROM), muscle soreness, and serum creatine kinase (CK) activity were measured before, immediately after, and 1\u20107\u00a0days after exercise. Plasma interleukin\u20108 (IL\u20108) was measured before, immediately after, 12\u00a0hours after, and 1\u20107\u00a0days after exercise. The changes were compared over time. In Exp. 1, no significant differences were found between CUR and PLA subjects for each parameter. However, increases in IL\u20108 were significantly reduced 12\u00a0hours after exercise when CUR was ingested before exercise. In Exp. 2, compared to the PLA subjects, MVC torque and ROM were higher 3\u20107\u00a0days and 2\u20107\u00a0days after exercise (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), respectively, whereas muscle soreness and CK activity were lower 3\u20106\u00a0days and 5\u20107\u00a0days after exercise (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), respectively, in CUR subjects. CUR ingestion before exercise could attenuate acute inflammation, and after exercise could attenuate muscle damage and facilitate faster recovery.<\/jats:p>","DOI":"10.1111\/sms.13373","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T18:38:30Z","timestamp":1545244710000},"page":"524-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3105-2017","authenticated-orcid":false,"given":"Yoko","family":"Tanabe","sequence":"first","affiliation":[{"name":"Department of Sport Research Japan Institute of Sports Sciences  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Chino","sequence":"additional","affiliation":[{"name":"Department of Sport 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