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Fifteen sedentary men (20\u201025\u00a0years) performed 5 sets of 10 eccentric contractions with 80% of MVC load for the elbow flexors (EF), elbow extensors (EE), pectoralis, knee extensors (KE), knee flexors (KF), plantar flexors (PF), latissimus, abdominis, and erector spinae (ES) in a randomized order and repeated the same exercises 2\u00a0weeks later. MVC decreased at 1 (16%\u201057%) to 4 (13%\u201049%) days, DOMS developed (peak: 43\u201070\u00a0mm), and CK activity (peak: 23\u00a0238\u2010207\u00a0304\u00a0IU\/L) and Mb concentration showed large increases after the first bout. The magnitude of decrease in MVC was greater (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05) for EF, EE, and PEC than others and for KF than KE, PF, and ES. DOMS was greater (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05) for EF, EE, and ES than others. Changes in all measures were smaller (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.05) after the second than the first bout, and the magnitude of the repeated bout effect was similar among the muscles. Plasma CK activity and Mb concentration did not increase significantly after the second exercise bout. It was concluded that muscle damage was greater for arm than leg muscles, and muscle proteins in the blood increased to a critical level after unaccustomed whole\u2010body resistance exercises, but the magnitude of damage was largely attenuated for all muscles similarly after the second bout.<\/jats:p>","DOI":"10.1111\/sms.13388","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T13:05:07Z","timestamp":1548075907000},"page":"725-735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Damage and the repeated bout effect of arm, leg, and trunk muscles induced by eccentric resistance exercises"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8769-1833","authenticated-orcid":false,"given":"Trevor C.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Physical Education National Taiwan Normal University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Jen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Physical Education National Taiwan Normal University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min\u2010Jyue","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Physical Education National Taiwan Normal University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho\u2010Seng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physical Education National Taiwan Normal University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo\u2010Wei","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Exercise and Health Sciences University of Taipei Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin\u2010Lian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physical Education, Health and Recreation National Chiayi University Chiayi County Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7373-4994","authenticated-orcid":false,"given":"Kazunori","family":"Nosaka","sequence":"additional","affiliation":[{"name":"Centre for Exercise and Sports Science Research, School of Medical and Health Sciences Edith Cowan University Joondalup Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.05.007"},{"key":"e_1_2_7_3_1","unstructured":"U.S. Department of Health and Human Services.Physical Activity Guidelines for Americans 2nd ed.Washington DC:U.S. Department of Health and Human Services;2018.https:\/\/health.gov\/paguidelines\/second-edition\/Updated December 28 2018. 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