{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:09:15Z","timestamp":1791212955000,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003032","name":"Association Nationale de la Recherche et de la Technologie","doi-asserted-by":"publisher","award":["2014\/0391"],"award-info":[{"award-number":["2014\/0391"]}],"id":[{"id":"10.13039\/501100003032","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>While obstructive sleep apnea (OSA) increases chemoreflex, leading to an autonomic dysfunction in the long term, no studies have yet assessed the potential benefit of exercise on cardiac autonomic activity in these patients. The aim of this study was to evaluate potential improvement in cardiac autonomic function (CAF) measured through heart rate variability (HRV) after a 9\u2010month physical activity program in patients with OSA. Seventy\u2010four patients with moderate OSA, aged 40\u201080\u00a0years, were randomly assigned to an exercise group (n\u00a0=\u00a036, 3\u00a0\u00d7\u00a01\u00a0h\/wk) or a control group (n\u00a0=\u00a038) during 9\u00a0months. Linear and nonlinear HRV parameters were measured during night using a Holter ECG. After 9\u00a0months, mean R\u2010R intervals increased in the exercise group without any changes in HRV parameters, while controls decreased global (standard deviation of normal\u2010to\u2010normal intervals, total power) and parasympathetic (root mean square successive difference of N\u2010Ns, very low frequency, high frequency, and standard deviation of the instantaneous beat\u2010to\u2010beat variability) indices of HRV (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 for all). Significant correlations with moderate effect size were found between changes in apnea severity and changes in R\u2010R intervals (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Improvement in moderate\u2010to\u2010vigorous physical activity was also correlated to improvement in nocturnal oxygen parameters (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). In conclusion, supervised community physical activity may prevent a decline in nighttime CAF observed in nontreated community\u2010dwelling patients with moderate OSA over a 9\u2010month period. Thus, beyond apnea\u2010hypopnea index improvement, exercise may be cardioprotective in OSA patients through bradycardia, CAF preservation, and VO<jats:sub>2peak<\/jats:sub> increase.<\/jats:p>","DOI":"10.1111\/sms.13447","type":"journal-article","created":{"date-parts":[[2019,5,2]],"date-time":"2019-05-02T17:42:38Z","timestamp":1556818958000},"page":"1254-1262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Effect of exercise training on heart rate variability in patients with obstructive sleep apnea: A randomized controlled trial"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6415-7694","authenticated-orcid":false,"given":"Mathieu","family":"Berger","sequence":"first","affiliation":[{"name":"Laboratoire SNA\u2010EPIS, EA 4607, Universit\u00e9 de Lyon Universit\u00e9 Jean Monnet Saint\u2010Etienne Saint\u2010Etienne France"},{"name":"Service de Physiologie Clinique et de 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