{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:21:02Z","timestamp":1793161262918,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,7,28]],"date-time":"2019-07-28T00:00:00Z","timestamp":1564272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>We sought to determine whether early increases in cross\u2010sectional area (CSA) of different muscles composing the quadriceps with low\u2010load resistance training with blood flow restriction (LL\u2010BFR) were mainly driven by muscle hypertrophy or by edema\u2010induced swelling. We also compared these changes to those promoted by high\u2010load resistance training (HL\u2010RT). In a randomized within\u2010subject design, fifteen healthy, untrained men were submitted to magnetic resonance imaging (MRI) for CSA and edema\u2010induced muscle swelling assessment (fast spin echo inversion recovery, FSE\u2010STIR). MRI was performed in LL\u2010BFR and HL\u2010RT at baseline (W0) and after 3\u00a0weeks (W3), with a further measure after 6\u00a0weeks (W6) for HL\u2010RT. Participants were also assessed at these time points for indirect muscle damage markers (range of motion, ROM; muscle soreness, SOR). CSA significantly increased for all the quadriceps muscles, for both LL\u2010BFR and HL\u2010RT at W3 (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) compared to W0. However, FSE\u2010STIR was elevated at W3 for all the quadriceps muscles only for HL\u2010RT (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001), not LL\u2010BFR (all <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). Significant increases and decreases were shown in SOR and ROM, respectively, for HL\u2010RT in W3 compared to W0 (both <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), while these changes were mitigated at W6 compared to W0 (both <jats:italic>P<\/jats:italic>\u00a0&gt;\u00a0.05). No significant changes in SOR or ROM were demonstrated for LL\u2010BFR across the study. Early increases in CSA with LL\u2010BFR seem to occur without the presence of muscle edema, whereas initial gains obtained by HL\u2010RT were influenced by muscle edema, in addition to muscle hypertrophy.<\/jats:p>","DOI":"10.1111\/sms.13516","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T07:28:34Z","timestamp":1562570914000},"page":"1713-1726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Differential muscle hypertrophy and edema responses between high\u2010load and low\u2010load exercise with blood flow restriction"],"prefix":"10.1111","volume":"29","author":[{"given":"Fabiano Freitas","family":"Shiromaru","sequence":"first","affiliation":[{"name":"Strength Training Study and Research Group Institute of Health Sciences, Paulista University S\u00e3o Paulo 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