{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T05:54:15Z","timestamp":1793080455453,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,17]],"date-time":"2019-11-17T00:00:00Z","timestamp":1573948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>This study evaluated whether the reduction of prefrontal cortex oxygenation (ScO<jats:sub>2<\/jats:sub>) during maximal exercise depends on the hyperventilation\u2010induced hypocapnic attenuation of middle cerebral artery blood velocity (MCA <jats:italic>V<\/jats:italic><jats:sub>mean<\/jats:sub>). Twelve endurance\u2010trained males (age: 25\u00a0\u00b1\u00a03\u00a0years, height: 183\u00a0\u00b1\u00a08\u00a0cm, weight: 75\u00a0\u00b1\u00a09\u00a0kg; mean\u00a0\u00b1\u00a0SD) performed in three separate laboratory visits, a maximal oxygen uptake (VO<jats:sub>2<\/jats:sub>max) test, an isocapnic (end\u2010tidal CO<jats:sub>2<\/jats:sub> tension (PetCO<jats:sub>2<\/jats:sub>) clamped at 40\u00a0\u00b1\u00a01\u00a0mmHg), and an ambient air controlled\u2010pace constant load high\u2010intensity ergometer cycling to exhaustion, while MCA <jats:italic>V<\/jats:italic><jats:sub>mean<\/jats:sub> (transcranial Doppler ultrasound) and ScO<jats:sub>2<\/jats:sub> (near\u2010infrared spectroscopy) were determined. Duration of exercise (12\u00a0min 25\u00a0s\u00a0\u00b1\u00a01\u00a0min 18\u00a0s) was matched by performing the isocapnic trial first. Pulmonary VO<jats:sub>2<\/jats:sub> was 90\u00a0\u00b1\u00a06% versus 93\u00a0\u00b1\u00a05% of the maximal value (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.012) and PetCO<jats:sub>2<\/jats:sub> 40\u00a0\u00b1\u00a01 versus 34\u00a0\u00b1\u00a04\u00a0mmHg (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) during the isocapnic and control trials, respectively. During the isocapnic trial MCA <jats:italic>V<\/jats:italic><jats:sub>mean<\/jats:sub> increased by 16\u00a0\u00b1\u00a013% until clamping was applied and continued to increase (by 14\u00a0\u00b1\u00a028%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.017) until the end of exercise, while there was no significant change during the control trial (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.071). In contrast, ScO<jats:sub>2<\/jats:sub> decreased similarly in both trials (\u22123.2\u00a0\u00b1\u00a05.1% and \u22124.1\u00a0\u00b1\u00a09.6%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001, isocapnic and control, respectively) at exhaustion. The reduction in prefrontal cortex oxygenation during maximal exercise does not depend solely on lowered cerebral blood flow as indicated by middle cerebral blood velocity.<\/jats:p>","DOI":"10.1111\/sms.13582","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T07:04:56Z","timestamp":1571987096000},"page":"399-407","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["CO<sub>2<\/sub> supplementation dissociates cerebral oxygenation and middle cerebral artery blood velocity during maximal cycling"],"prefix":"10.1111","volume":"30","author":[{"given":"Rasmus K.","family":"Hansen","sequence":"first","affiliation":[{"name":"Sport Sciences Department of Health Science and Technology Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Sport Sciences Department of 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