{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:04:29Z","timestamp":1790291069946,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T00:00:00Z","timestamp":1578009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>Exercise\u2010induced redistribution of tissue blood flow decreases the renal blood flow in an exercise intensity\u2010dependent manner. However, the acute effects of incremental short maximal exercise on renal tubular conditions remain unknown. The purpose of this study was to investigate the acute effects of incremental short maximal exercise on the urinary liver\u2010type fatty acid\u2010binding protein, which is a highly sensitive tubular biomarker that correlates excellently with peritubular capillary blood flow. A total of 116 adults (aged 24\u201083\u00a0years) without chronic kidney disease performed the incremental short maximal exercise using a cycling ergometer, wherein the exercise sequence consisted of commencing with a 2\u2010min workout period at 20\u00a0W (as a warm\u2010up period) and then followed by a 10\u201020\u00a0W increase every 1\u00a0minute until termination criteria were reached. Urinary samples were gathered before and immediately after the exercise to evaluate the concentrations of urinary creatinine, albumin, and liver\u2010type fatty acid\u2010binding protein. Urinary excretion levels of albumin and liver\u2010type fatty acid\u2010binding protein were significantly increased post\u2010exercise (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.008, respectively). Furthermore, the %\u00a0change in urinary liver\u2010type fatty acid\u2010binding protein levels after exercise was found to correlate independently with age, estimated glomerular filtration rate at baseline, and the %\u00a0change in urinary albumin (Model <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.451, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Our findings suggest that incremental short maximal exercise may lead to acute slightly adverse effects on tubular conditions, especially in young adults or adults with lower renal function, even without chronic kidney disease.<\/jats:p>","DOI":"10.1111\/sms.13618","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T07:19:12Z","timestamp":1576567152000},"page":"709-715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Incremental short maximal exercise increases urinary liver\u2010type fatty acid\u2010binding protein in adults without CKD"],"prefix":"10.1111","volume":"30","author":[{"given":"Keisei","family":"Kosaki","sequence":"first","affiliation":[{"name":"Faculty of Sport Sciences Waseda University Saitama Japan"},{"name":"Faculty of Health and Sport Sciences University of Tsukuba Ibaraki Japan"},{"name":"Japan Society for the Promotion of Science Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Kamijo\u2010Ikemori","sequence":"additional","affiliation":[{"name":"Department of Anatomy St. Marianna University School of Medicine Kanagawa Japan"},{"name":"Division of Nephrology and Hypertension Department of Internal Medicine St. Marianna University School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sugaya","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Department of Internal Medicine St. Marianna University School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Kumamoto","sequence":"additional","affiliation":[{"name":"Graduate School of Comprehensive Human Sciences University of Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Tanahashi","sequence":"additional","affiliation":[{"name":"Faculty of Health and Sport Sciences University of Tsukuba Ibaraki Japan"},{"name":"Department of Health and Sports Sciences Kyoto Pharmaceutical University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Japan Society for the Promotion of Science Tokyo Japan"},{"name":"Graduate School of Health and Sports Science Juntendo University Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjiro","family":"Kimura","sequence":"additional","affiliation":[{"name":"JCHO Tokyo Takanawa Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yugo","family":"Shibagaki","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Department of Internal Medicine St. Marianna University School of Medicine Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1642-4644","authenticated-orcid":false,"given":"Seiji","family":"Maeda","sequence":"additional","affiliation":[{"name":"Faculty of Health and Sport Sciences University of Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.734764"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c100048"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00373.2003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000038362.16740.A2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-018-01685-3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-018-1559-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12867"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.07.015"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-198401020-00003"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343417"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000481179"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)90589-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2004.12.003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2003.08.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-11-0342"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007010097"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-017-1385-x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.07.007"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.11.027"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-019-0273-z"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.3967"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21579"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13436"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63384-6"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00581.2007"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00269.2002"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.01.045"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2010.01354.x"}],"container-title":["Scandinavian Journal of Medicine &amp; Science in Sports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fsms.13618","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sms.13618","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/sms.13618","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sms.13618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T20:59:44Z","timestamp":1694033984000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sms.13618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,3]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/sms.13618"],"URL":"https:\/\/doi.org\/10.1111\/sms.13618","archive":["Portico"],"relation":{},"ISSN":["0905-7188","1600-0838"],"issn-type":[{"value":"0905-7188","type":"print"},{"value":"1600-0838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,3]]},"assertion":[{"value":"2019-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}