{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T09:52:30Z","timestamp":1781862750364,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study the effects of running with\/without the use of pain killers on urinary neutrophil gelatinase\u2010associated lipocalin (uNGAL) and other parameters of kidney function in recreational runners.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants of the 10\u2010 and 21.1\u2010km Weir Venloop race were enrolled and their urine samples collected before and after the run. Urine dipstick and other conventional tests used to assess kidney function were performed. The presence of ibuprofen, diclofenac, naproxen, and\/or paracetamol was assessed by LC\u2010MS\/MS. uNGAL was measured with a two\u2010step chemiluminescent immunoassay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NSAIDs\/analgesics were detected in urine of 5 (14.4%) 10\u2010km runners and 13 (28.9%) 21.1\u2010km runners. Only half\u2010marathon participants showed significant increases in uNGAL (pre: 11.7 [7.1\u201034.3] ng\/mL; post: 33.4 [17.4\u201050.4] ng\/mL; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0038). There was a significant effect of NSAID\/analgesic use on uNGAL increase (F<jats:sub>2, 76<\/jats:sub>\u00a0=\u00a04.210, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004). Post hoc tests revealed that uNGAL increased significantly in runners who tested positive for ibuprofen\/naproxen compared to runners who did not use any medications (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.045) or those who tested positive for paracetamol (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.033). Running distance had a significant influence on the increase in uNGAL (F<jats:sub>1, 53<\/jats:sub>\u00a0=\u00a04.741, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), specific gravity (F<jats:sub>1, 60<\/jats:sub>\u00a0=\u00a09.231, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01), urinary creatinine (F<jats:sub>1, 61<\/jats:sub>\u00a0=\u00a010.574, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01), albumin (F<jats:sub>1, 59<\/jats:sub>\u00a0=\u00a04.888, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05), and development of hematuria (\u03c7<jats:sup>2<\/jats:sup>(4)\u00a0=\u00a018.44, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Running distance and use of ibuprofen\/naproxen were identified as risk factors for uNGAL increase in recreational runners.<\/jats:p><\/jats:sec>","DOI":"10.1111\/sms.13755","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T21:43:50Z","timestamp":1593121430000},"page":"1888-1895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Non\u2010steroidal anti\u2010inflammatory drugs increase urinary neutrophil gelatinase\u2010associated lipocalin in recreational runners"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2209-3653","authenticated-orcid":false,"given":"Khrystyna O.","family":"Semen","sequence":"first","affiliation":[{"name":"Campus Venlo Maastricht University  Venlo The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick H. A.","family":"van der Doelen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry VieCuri Medical Center Noord\u2010Limburg  Venlo The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2355-4607","authenticated-orcid":false,"given":"Monique","family":"van der Lugt","sequence":"additional","affiliation":[{"name":"Emergency Department VieCuri Medical Center Noord\u2010Limburg  Venlo The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0823-2351","authenticated-orcid":false,"given":"Davy G. H. A.","family":"van Dam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine VieCuri Medical Center Noord\u2010Limburg  Venlo The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Reimer","sequence":"additional","affiliation":[{"name":"Medcaptain Europe BV  Andelst The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank R. 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L","family":"le Noble","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Maastricht University  Maastricht The Netherlands"},{"name":"Department of Intensive Care VieCuri Medical Center Noord\u2010Limburg  Venlo The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"The Statictics Portal.Number of participants in running\/jogging and trail running in the U.S. from 2006 to 2017 (in millions).https:\/\/www.statista.com\/topics\/1743\/running-and-jogging\/Accessed October 18 2019."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2017.03.005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1060094"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1249\/JSR.0000000000000491"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2008.01133.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0b013e31802b5be9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-198401020-00003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0000000000000253"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12947-015-0007-6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.01.045"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2010.01354.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2016.1225122"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016101127"},{"issue":"9","key":"e_1_2_6_15_1","first-page":"1585","article-title":"Variation of serum and urinary neutrophil gelatinase associated lipocalin (NGAL) after strenuous physical exercise","volume":"50","author":"Lippi G","year":"2012","journal-title":"Clin Chem Lab Med"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563214521795"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2016-206353"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2016-097372.317"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-002090"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.17159\/2078-516X\/2013\/v25i4a340"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/sports5010011"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/JSM.0000000000000619"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2009.12.008"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpp.12469"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/15438627.2017.1282356"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2010.02.004"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.12191213"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)82217-7"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330428"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200908-1214OC"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2011-0814"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389203717666160909125004"},{"key":"e_1_2_6_33_1","unstructured":"WetterstenNW MaiselAS.NGAL for the detection of AKI: more questions than answers.https:\/\/www.acc.org\/latest-in-cardiology\/articles\/2017\/03\/30\/10\/45\/ngal-for-the-detection-of-aki. 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