{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:34:08Z","timestamp":1791894848615,"version":"4.3.4"},"reference-count":54,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T00:00:00Z","timestamp":1595635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007109","name":"Universit\u00e0 degli Studi di Ferrara","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We tested the safety, feasibility, and effectiveness of blood flow restriction\u2010empowered low\u2010intensity interval walking exercise (BFR\u2010W) compared with conventional intensive overground walking (CON\u2010W) at improving gait speed and functional capacity in patients with multiple sclerosis (MS) and severe gait disabilities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>24 patients (58\u00a0\u00b1\u00a05\u00a0years; 7 males) with progressive MS (Expanded Disability Status Scale 5.5\u00a0\u2212\u00a06.5) were randomized to receive 12 rehabilitation sessions over 6\u00a0weeks. The BFR\u2010W group (n\u00a0=\u00a012) performed interval walking (speed paced by a metronome that increased weekly) with BFR bands at the thighs. The CON\u2010W group (n\u00a0=\u00a012) received physiotherapist\u2010assisted overground walking therapy. The primary outcome was gait speed, measured by the timed 25\u2010foot walk test. Secondary outcomes included walking endurance, balance, strength, fatigue, and quality of life. The measurements were collected at baseline, at the end of training, and a 6\u2010week follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The two groups did not present any baseline difference. BFR\u2010W group safely walked without limitations due to sleeve compression, with lower increase in perceived exertion (RPE) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and heart rate (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.031) compared with the CON\u2010W. Gait speed improved significantly in both groups (BFR\u2010W\u00a0+\u00a013%; CON\u2010W\u00a0+\u00a05%) with greater increases in the BFR\u2010W group at end of the training (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001) and at the follow\u2010up (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.041). Most of the secondary outcomes significantly improved in the two groups, without between\u2010group differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Slow interval walking with moderate BFR to the lower limbs was superior to overground walking in improving gait speed in patients with MS with a lower training load and a more durable clinical benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/sms.13764","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T17:05:48Z","timestamp":1594314348000},"page":"1999-2009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Effectiveness of blood flow\u2010restricted slow walking on mobility in severe multiple sclerosis: A pilot randomized trial"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5763-3069","authenticated-orcid":false,"given":"Nicola","family":"Lamberti","sequence":"first","affiliation":[{"name":"Department of Biomedical and Surgical Specialties Sciences Section of Sport Sciences University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Straudi","sequence":"additional","affiliation":[{"name":"Neuroscience and Rehabilitation Department Ferrara University Hospital Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Donadi","sequence":"additional","affiliation":[{"name":"Neuroscience and Rehabilitation Department Ferrara University Hospital Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1780-7471","authenticated-orcid":false,"given":"Hirofumi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Cardiovascular Aging Research Laboratory Department of Kinesiology and Health Education The University of Texas at Austin Austin TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nino","family":"Basaglia","sequence":"additional","affiliation":[{"name":"Neuroscience and Rehabilitation Department Ferrara University Hospital Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Manfredini","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Surgical Specialties Sciences Section of Sport Sciences University of Ferrara Ferrara Italy"},{"name":"Neuroscience and Rehabilitation Department Ferrara University Hospital Ferrara 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