{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:19:39Z","timestamp":1790741979208,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003759","name":"Universidad Polit\u00e9cnica de Madrid","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003759","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The use of oral contraceptives (OCs) by female athletes may lead to improved iron status, possibly through the regulation of hepcidin by sex hormones. The present work investigates the response of hepcidin and interleukin\u20106 (IL\u20106) to an interval exercise in both phases of the OC cycle. Sixteen endurance\u2010trained OC users (age 25.3\u00a0\u00b1\u00a04.7\u00a0years; height 162.4\u00a0\u00b1\u00a05.7\u00a0cm; body mass 56.0\u00a0\u00b1\u00a05.7\u00a0kg; body fat percentage 24.8\u00a0\u00b1\u00a06.0%; peak oxygen consumption [VO<jats:sub>2peak<\/jats:sub>]: 47.4\u00a0\u00b1\u00a05.5\u00a0mL min<jats:sup>\u22121<\/jats:sup> kg<jats:sup>\u22121<\/jats:sup>) followed an identical interval running protocol during the withdrawal and active pill phases of the OC cycle. This protocol consisted of 8\u00a0\u00d7\u00a03\u00a0minutes bouts at 85% VO<jats:sub>2peak<\/jats:sub> speed with 90\u00a0seconds recovery intervals. Blood samples were collected pre\u2010exercise, and at 0\u00a0hour, 3\u00a0hours, and 24\u00a0hours post\u2010exercise. Pre\u2010exercise 17\u03b2\u2010estradiol was lower (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) during the active pill than the withdrawal phase (7.91\u00a0\u00b1\u00a01.81 vs 29.36\u00a0\u00b1\u00a06.45\u00a0pg\/mL [mean\u00a0\u00b1\u00a0SEM]). No differences were seen between the OC phases with respect to hepcidin or IL\u20106 concentrations, whether taking all time points together or separately. However, within the withdrawal phase, hepcidin concentrations were higher at 3\u00a0hours post\u2010exercise (3.33\u00a0\u00b1\u00a00.95\u00a0nmol\/L) than at pre\u2010exercise (1.04\u00a0\u00b1\u00a00.20\u00a0nmol\/L; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005) and 0\u00a0hour post\u2010exercise (1.41\u00a0\u00b1\u00a00.38\u00a0nmol\/L; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.045). Within both OC phases, IL\u20106 was higher at 0\u00a0hour post\u2010exercise than at any other time point (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Similar trends in hepcidin and IL\u20106 concentrations were seen at the different time points during both OC phases. OC use led to low 17\u03b2\u2010estradiol concentrations during the active pill phase but did not affect hepcidin. This does not, however, rule out estradiol affecting hepcidin levels.<\/jats:p>","DOI":"10.1111\/sms.13894","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T12:09:35Z","timestamp":1606651775000},"page":"643-652","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hepcidin response to interval running exercise is not affected by oral contraceptive phase in endurance\u2010trained women"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0456-1222","authenticated-orcid":false,"given":"V\u00edctor M.","family":"Alfaro\u2010Magallanes","sequence":"first","affiliation":[{"name":"LFE Research Group Department of Health and Human Performance Faculty of Physical Activity and Sport Sciences Universidad Polit\u00e9cnica de Madrid (UPM) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Barba\u2010Moreno","sequence":"additional","affiliation":[{"name":"LFE Research Group Department of Health and Human Performance Faculty of Physical Activity and Sport Sciences Universidad Polit\u00e9cnica de Madrid (UPM) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9331-4564","authenticated-orcid":false,"given":"Beatriz","family":"Rael","sequence":"additional","affiliation":[{"name":"LFE Research Group Department of Health and Human Performance Faculty of Physical Activity and Sport Sciences Universidad Polit\u00e9cnica de Madrid (UPM) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9754-5565","authenticated-orcid":false,"given":"Nuria","family":"Romero\u2010Parra","sequence":"additional","affiliation":[{"name":"LFE Research Group Department of Health and Human Performance Faculty of Physical Activity and Sport Sciences Universidad Polit\u00e9cnica de Madrid (UPM) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3217-7786","authenticated-orcid":false,"given":"Miguel A.","family":"Rojo\u2010Tirado","sequence":"additional","affiliation":[{"name":"LFE Research Group Department of Health and Human Performance Faculty of Physical Activity and Sport Sciences Universidad Polit\u00e9cnica de Madrid (UPM) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1631-8182","authenticated-orcid":false,"given":"Pedro J.","family":"Benito","sequence":"additional","affiliation":[{"name":"LFE Research Group Department of Health and Human Performance Faculty of Physical Activity and Sport Sciences Universidad Polit\u00e9cnica de Madrid (UPM) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorine W.","family":"Swinkels","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Translational Metabolic Laboratory (TML 830) Radboud University Medical Center Nijmegen The Netherlands"},{"name":"Hepcidinanalysis.com Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coby M.","family":"Laarakkers","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Translational Metabolic Laboratory (TML 830) Radboud University Medical Center Nijmegen The Netherlands"},{"name":"Hepcidinanalysis.com Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6215-0093","authenticated-orcid":false,"given":"\u00c1ngel E.","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Department of National Center of Sport Medicine, Health and Sports AEPSAD Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4871-8682","authenticated-orcid":false,"given":"Ana B.","family":"Peinado","sequence":"additional","affiliation":[{"name":"LFE Research Group Department of Health and Human Performance Faculty of Physical Activity and Sport Sciences Universidad Polit\u00e9cnica de Madrid (UPM) Madrid 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