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Although it may function as an intracellular second messenger, most of its effects are induced extracellularly via activation of a family of five specific membrane receptors. Sphingosine\u20101\u2010phosphate is enriched in plasma, where it is transported by high\u2010density lipoprotein and albumin, as well as in erythrocytes and platelets which store and release large amounts of this sphingolipid. Sphingosine\u20101\u2010phosphate regulates a host of cellular processes such as growth, proliferation, differentiation, migration, and apoptosis suppression. It was also shown to play an important role in skeletal muscle physiology and pathophysiology. In recent years, S1P metabolism in both muscle and blood was found to be modulated by exercise. In this review, we summarize the current knowledge on the effect of acute exercise and training on S1P metabolism, highlighting the role of this sphingolipid in skeletal muscle adaptation to physical effort.<\/jats:p>","DOI":"10.1111\/sms.13907","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T01:57:27Z","timestamp":1608515847000},"page":"945-955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Sphingosine\u20101\u2010phosphate in acute exercise and training"],"prefix":"10.1111","volume":"31","author":[{"given":"Katarzyna","family":"Hodun","sequence":"first","affiliation":[{"name":"Department of Physiology Medical University of Bialystok Bialystok Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Chabowski","sequence":"additional","affiliation":[{"name":"Department of Physiology Medical University of Bialystok Bialystok 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