{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:39:44Z","timestamp":1793651984924,"version":"4.5.1"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Exercise during cancer treatment improves cancer\u2010related fatigue (CRF), but the importance of exercise intensity for CRF is unclear. We compared the effects of high\u2010 vs low\u2010to\u2010moderate\u2010intensity exercise with or without additional behavior change support (BCS) on CRF in patients undergoing (neo\u2010)adjuvant cancer treatment. This was a multicenter, 2x2 factorial design randomized controlled trial (Clinical Trials NCT02473003) in Sweden. Participants recently diagnosed with breast (n\u00a0=\u00a0457), prostate (n\u00a0=\u00a097) or colorectal (n\u00a0=\u00a023) cancer undergoing (neo\u2010)adjuvant treatment were randomized to high intensity (n\u00a0=\u00a0144), low\u2010to\u2010moderate intensity (n\u00a0=\u00a0144), high intensity with BCS (n\u00a0=\u00a0144) or low\u2010to\u2010moderate intensity with BCS (n\u00a0=\u00a0145). The 6\u2010month exercise intervention included supervised resistance training and home\u2010based endurance training. CRF was assessed by Multidimensional Fatigue Inventory (MFI, five subscales score range 4\u201020), and Functional Assessment of Chronic Illness Therapy\u2010Fatigue scale (FACIT\u2010F, score range 0\u201052). Multiple linear regression for main factorial effects was performed according to intention\u2010to\u2010treat, with post\u2010intervention CRF as primary endpoint. Overall, 577 participants (mean age 58.7\u00a0years) were randomized. Participants randomized to high\u2010 vs low\u2010to\u2010moderate\u2010intensity exercise had lower physical fatigue (MFI Physical Fatigue subscale; mean difference \u22121.05 [95% CI: \u22121.85, \u22120.25]), but the difference was not clinically important (ie &lt;2). We found no differences in other CRF dimensions and no effect of additional BCS. There were few minor adverse events. For CRF, patients undergoing (neo\u2010)adjuvant treatment for breast, prostate or colorectal cancer can safely exercise at high\u2010 or low\u2010to\u2010moderate intensity, according to their own preferences. Additional BCS does not provide extra benefit for CRF in supervised, well\u2010controlled exercise interventions.<\/jats:p>","DOI":"10.1111\/sms.13930","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T23:14:51Z","timestamp":1612394091000},"page":"1144-1159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Does exercise intensity matter for fatigue during (neo\u2010)adjuvant cancer treatment? The Phys\u2010Can randomized clinical trial"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2068-4708","authenticated-orcid":false,"given":"Ingrid","family":"Demmelmaier","sequence":"first","affiliation":[{"name":"Department of Public Health and Caring Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah L.","family":"Brooke","sequence":"additional","affiliation":[{"name":"Department of Public Health and Caring Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Henriksson","sequence":"additional","affiliation":[{"name":"Department of Public Health and Caring Sciences Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Sophie","family":"Mazzoni","sequence":"additional","affiliation":[{"name":"Department of Public Health and Caring Sciences Uppsala University 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