{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T02:17:44Z","timestamp":1789265864027,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>Pharmacological and non\u2010pharmacological therapies are simultaneously prescribed when treating hypertensive individuals with elevated cardiovascular risk (ie, metabolic syndrome individuals). However, it is unknown if the interactions between antihypertensive medication (AHM) and lifestyle interventions (ie, exercise training) may result in a better ambulatory blood pressure (ABP) control. To test this hypothesis, 36 hypertensive individuals with metabolic syndrome (MetS) under long\u2010term prescription with AHM targeting the renin\u2010angiotensin\u2010aldosterone system (RAAS) were recruited. Before and after 4\u00a0months of high\u2010intensity interval training (HIIT), participants completed two trials in a double\u2010blind, randomized order: (a) placebo trial consisting of AHM withdrawal for 3\u00a0days and (b) AHM trial where individuals held their habitual dose of AHM. In each trial, 24\u2010h mean arterial pressure (MAP) was monitored and considered the primary study outcome. Secondary outcomes included plasma renin activity (PRA) and aldosterone concentration to confirm withdrawal effects on RAAS, along with the analysis of urine albumin\u2010to\u2010creatinine ratio (UACR) to assess kidney function. The results showed main effects from AHM and HIIT reducing 24\u2010h MAP (\u22125.7\u00a0mmHg, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001 and \u22122.3\u00a0mmHg, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.007, respectively). However, there was not interaction between AHM and HIIT on 24\u2010h MAP (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.240). There was a main effect of AHM increasing PRA (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) but no effect on plasma aldosterone concentration (<jats:italic>p<\/jats:italic>\u00a0= 0.368). HIIT did not significantly improve RAAS hormones or the UACR. In conclusion, AHM and HIIT have independent and additive effects in lowering ABP. These findings support the combination of habitual AHM with exercise training with the goal to reduce ABP in hypertensive MetS individuals.<\/jats:p>","DOI":"10.1111\/sms.13949","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T17:55:52Z","timestamp":1614880552000},"page":"1411-1419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effects of antihypertensive medication and high\u2010intensity interval training in hypertensive metabolic syndrome individuals"],"prefix":"10.1111","volume":"31","author":[{"given":"Miguel","family":"Ramirez\u2010Jimenez","sequence":"first","affiliation":[{"name":"Exercise Physiology Lab at Toledo University of Castilla\u2010La Mancha Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Morales\u2010Palomo","sequence":"additional","affiliation":[{"name":"Exercise Physiology Lab at Toledo University of 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