{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:28:36Z","timestamp":1784165316012,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>We used a within\u2010subject, cross\u2010over design study to compare the impact of 4\u2010weeks' resistance (RT) versus endurance (END) training on vascular function. We subsequently explored the association of intra\u2010individual effects of RT versus END on vascular function with a single nucleotide polymorphism (SNP) of the<jats:italic>NOS3<\/jats:italic>gene. Thirty\u2010five healthy males (21\u00a0\u00b1\u00a02\u00a0years old) were genotyped for the<jats:italic>NOS3<\/jats:italic>rs2070744 SNP and completed both training modalities. Participants completed 12 sessions over a 4\u2010week period, either RT (leg\u2010extension) or END (cycling) training in a randomized, balanced cross\u2010over design with a 3\u2010week washout period. Participants performed peak oxygen uptake (peak VO<jats:sub>2<\/jats:sub>) and leg\u2010extension single\u2010repetition maximum (1\u2010RM) testing, and vascular function assessment using flow\u2010mediated dilation (FMD) on 3 separated days pre\/post\u2010training. Peak VO<jats:sub>2<\/jats:sub>increased after END (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001), while 1\u2010RM increased after RT (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001). FMD improved after 4\u2010weeks\u2019 training (time effect:<jats:italic>p\u00a0<\/jats:italic>=\u00a00.006), with no difference between exercise modalities (interaction effect:<jats:italic>p\u00a0<\/jats:italic>=\u00a00.92). No relation was found between individual changes (delta, pre\u2010post) in FMD to both types of training (R<jats:sup>2<\/jats:sup>\u00a0=\u00a00.06,<jats:italic>p\u00a0<\/jats:italic>=\u00a00.14). Intra\u2010individual changes in FMD following END and RT were associated with the<jats:italic>NOS3<\/jats:italic>SNP, with TT homozygotes significantly favoring only END (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.016) and TC\/CC tending to favor RT only (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.056). Although both training modes improved vascular function, significant intra\u2010individual variation in the adaptation of FMD was found. The association with<jats:italic>NOS3<\/jats:italic>genotype suggests a genetic predisposition to FMD adapting to a specific mode of chronic exercise. This study therefore provides novel evidence for personalized exercise training to optimize vascular health.<\/jats:p>","DOI":"10.1111\/sms.13975","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T11:06:23Z","timestamp":1619435183000},"page":"1683-1692","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Intra\u2010individual differences in the effect of endurance versus resistance training on vascular function: A cross\u2010over study"],"prefix":"10.1111","volume":"31","author":[{"given":"Ellen Adele","family":"Dawson","sequence":"first","affiliation":[{"name":"Research Institute for Sport and Exercise Sciences Liverpool John Moores University Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahare","family":"Sheikhsaraf","sequence":"additional","affiliation":[{"name":"Research Institute for Sport and Exercise Sciences Liverpool John Moores University 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