{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:52:46Z","timestamp":1790430766296,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T00:00:00Z","timestamp":1623024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Ultra\u2010endurance sports are growing in popularity but can be associated with adverse health effects, such as exercise\u2010induced muscle damage (EIMD), which can lead to exertional rhabdomyolysis. Circulating microRNAs (miRNAs) may be useful to approach the degree of EIMD. We aimed to (1) investigate the relevance of circulating miRNAs as biomarkers of muscle damage and (2) examine the acute response of skeletal\/cardiac muscle and kidney biomarkers to a 24\u2010h run in elite athletes. Eleven elite athletes participated in the 24\u2010h run World Championships. Counter\u2010movement jump (CMJ), creatine kinase (CK), myoglobin (Mb), creatinine (Cr), high\u2010sensitive cardiac troponin T (hs\u2010cTnT), and muscle\u2010specific miRNA (myomiR) levels were measured before, immediately after, and 24 and 48h after the race. CMJ height was reduced immediately after the race (\u221284.0\u00a0\u00b1\u00a025.2%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) and remained low at 24\u00a0h (\u221243.6\u00a0\u00b1\u00a020.4%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.002). We observed high CK activity (53\u00a0239\u00a0\u00b1\u00a063\u00a0608 U\/L,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) immediately after the race, and it remained elevated 24h after (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.01). Circulating myomiR levels (miR\u20101\u20103p, miR\u2010133a\u20103p, miR\u2010133b, miR\u2010208a\u20103p, miR\u2010208b\u20103p, and miR\u2010499a\u20105p) were elevated immediately after the 24\u2010h run (fold changes: 18\u2013124,723,\n                    <jats:italic>p<\/jats:italic>\n                    &lt;0.001) and significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05) correlated or tended to significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.07) correlate with the reduction in CMJ height at 24\u00a0h. We found no significant correlation between CMJ height loss at 24\u00a0h and CK (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.23) or Mb (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.41) values. All elite ultramarathon runners included in our study were diagnosed with exertional rhabdomyolysis after the 24\u2010h ultramarathon race. MyomiR levels may be useful to approach the degree of muscle damage.\n                  <\/jats:p>","DOI":"10.1111\/sms.14000","type":"journal-article","created":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T09:39:09Z","timestamp":1621676349000},"page":"1782-1795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Circulating microRNAs after a 24\u2010h ultramarathon run in relation to muscle damage markers in elite athletes"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-0236","authenticated-orcid":false,"given":"Emeric","family":"Chalchat","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Physiologie des Exercices et Activit\u00e9s en Conditions Extr\u00eames D\u00e9partement Environnements Op\u00e9rationnels Institut de Recherche Biom\u00e9dicale des Arm\u00e9es  Bretigny\u2010Sur\u2010Orge France"},{"name":"AME2P Universit\u00e9 Clermont Auvergne  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyne","family":"Charlot","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Physiologie des Exercices et Activit\u00e9s en Conditions Extr\u00eames D\u00e9partement Environnements Op\u00e9rationnels Institut de Recherche Biom\u00e9dicale des Arm\u00e9es  Bretigny\u2010Sur\u2010Orge France"},{"name":"LBEPS Univ Evry IRBA Universit\u00e9 Paris Saclay  Evry France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Garcia\u2010Vicencio","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Physiologie des Exercices et Activit\u00e9s en Conditions Extr\u00eames D\u00e9partement Environnements Op\u00e9rationnels Institut de Recherche Biom\u00e9dicale des Arm\u00e9es  Bretigny\u2010Sur\u2010Orge France"},{"name":"LBEPS Univ Evry IRBA Universit\u00e9 Paris Saclay  Evry 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Biom\u00e9dicale des Arm\u00e9es  Bretigny\u2010Sur\u2010Orge France"},{"name":"LBEPS Univ Evry IRBA Universit\u00e9 Paris Saclay  Evry France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Bompard","sequence":"additional","affiliation":[{"name":"H\u00f4pital d\u2019Instruction des Arm\u00e9es Percy  Clamart France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Farges","sequence":"additional","affiliation":[{"name":"Centre Hospitalier d\u2019Albi  Albi France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Martin","sequence":"additional","affiliation":[{"name":"AME2P Universit\u00e9 Clermont Auvergne  Clermont\u2010Ferrand France"},{"name":"Institut Universitaire de France (IUF)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyprien","family":"Bourrilhon","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Physiologie des Exercices et 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1123\/ijspp.2016-0237"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12970-020-00364-7"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01202.2009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-011-2135-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e01913"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-018-0385-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17461391.2020.1746837"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13897"},{"issue":"2","key":"e_1_2_9_10_1","first-page":"85","article-title":"Acute kidney injury: definition, pathophysiology and clinical 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