{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T23:53:22Z","timestamp":1771026802439,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>This study aimed to determine deficits in knee extensor muscle function through the torque\u2010time and torque\u2010velocity relationships and whether these deficits are associated with reduced functional performance in postmenopausal women with knee osteoarthritis (KOA). A clinical sample of postmenopausal women with established KOA (<jats:italic>n<\/jats:italic>\u00a0=\u00a018, \u226555\u00a0years) was compared to an age\u2010matched healthy control sample (CON) (<jats:italic>n<\/jats:italic>\u00a0=\u00a026). The deficits in different parameters of the knee extensor torque\u2010time (maximal isometric torque and rate of torque development) and torque\u2010velocity relationship (maximum muscle power, maximal velocity and torque at 0\u2013500\u00b0\u00b7s<jats:sup>\u22121<\/jats:sup>) were assessed through a protocol consisting of isometric, isotonic and isokinetic tests. Functional performance was evaluated with sit\u2010to\u2010stand and stair\u2010climbing tasks using a sensor\u2010based technology (ie, time\u2010 and power\u2010based outcomes). Postmenopausal women with KOA showed reduced maximal isometric torque (Hedge's <jats:italic>g<\/jats:italic> effect size (<jats:italic>g<\/jats:italic>)\u00a0=\u00a01.05, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.001) and rate of torque development (<jats:italic>g<\/jats:italic>\u00a0=\u00a00.77\u20121.17, all <jats:italic>p\u00a0<\/jats:italic>\u2264\u00a00.02), combined with impaired torque production at slow to moderate velocities (<jats:italic>g<\/jats:italic>\u00a0=\u00a00.92\u20121.70, <jats:italic>p\u00a0<\/jats:italic>\u2264\u00a00.004), but not at high or maximal velocities (<jats:italic>g<\/jats:italic>\u00a0=\u00a00.16, <jats:italic>p\u00a0<\/jats:italic>&gt;\u00a00.05). KOA were slower (<jats:italic>g<\/jats:italic>\u00a0=\u00a00.81\u20120.92, <jats:italic>p\u00a0<\/jats:italic>\u2264\u00a00.011) and less powerful (<jats:italic>g<\/jats:italic>\u00a0=\u00a01.11\u20121.29, <jats:italic>p\u00a0<\/jats:italic>\u2264\u00a00.001) during functional tasks. Additionally, knee extensor deficits were moderately associated with power deficits in stair climbing (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.492\u20120.659). To conclude, knee extensor muscle weakness was presented in postmenopausal women with KOA, not only as limited maximal and rapid torque development during isometric contractions, but also dynamically at low to moderate velocities. These deficits were related to impaired functional performance. The assessment of knee extensor muscle weakness through the torque\u2010time and torque\u2010velocity relationships might enable individual targets for tailored exercise interventions in KOA.<\/jats:p>","DOI":"10.1111\/sms.14035","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T08:35:54Z","timestamp":1629362154000},"page":"2144-2155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Reduced knee extensor torque production at low to moderate velocities in postmenopausal women with knee osteoarthritis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-7476","authenticated-orcid":false,"given":"Carlos","family":"Rodriguez\u2010Lopez","sequence":"first","affiliation":[{"name":"GENUD Toledo Research Group Universidad de Castilla\u2010La Mancha Toledo Spain"},{"name":"CIBER of Frailty and Healthy Aging (CIBERFES) Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Beckw\u00e9e","sequence":"additional","affiliation":[{"name":"Rehabilitation Research Group Department of Physiotherapy, Human Physiology and Anatomy Faculty of Physical Education &amp; Physiotherapy Vrije Universiteit Brussel Brussels Belgium"},{"name":"Frailty in Ageing Research Department Vrije Universiteit Brussel Brussels Belgium"},{"name":"Research Group MOVANT Department of Rehabilitation Sciences and Physiotherapy (REVAKI) University of Antwerp Wilrijk Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank P.","family":"Luyten","sequence":"additional","affiliation":[{"name":"Department of Development &amp; Regeneration Skeletal Biology and Engineering Research Center KU Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Van Assche","sequence":"additional","affiliation":[{"name":"Musculoskeletal Rehabilitation Research Group Department of Rehabilitation Sciences KU Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4547-589X","authenticated-orcid":false,"given":"Evelien","family":"Van Roie","sequence":"additional","affiliation":[{"name":"Physical Activity, Sports &amp; 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