{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:31:45Z","timestamp":1782253905261,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:p>The present study compared the first (EC1) and second (EC2) bouts of whole\u2010body eccentric exercises to examine the effects of the magnitude of muscle damage on changes in blood bone markers. Fifteen sedentary young men performed nine eccentric exercises of arm, leg, and trunk muscles, and repeated them 2\u00a0weeks later. Blood samples were taken before and 2\u00a0h and 1\u20135\u00a0days following each bout to analyze plasma creatine kinase (CK) activity and myoglobin concentration, serum tartrate\u2010resistant acid phosphatase (TRAP), type 1 C\u2010terminal telopeptide (CTX\u20101), procollagen type I N\u2010terminal propeptide (P1NP), bone\u2010specific alkaline phosphatase (BAP), undercarboxylated\u2010osteocalcin (ucOCN), carboxylated\u2010osteocalcin (cOCN), and leptin concentrations. All except ucOCN changed significantly (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05) after both bouts. When comparing bouts for peak changes, P1NP (bone formation marker) and CTX\u20101 (bone resorption marker) increased less after EC2 (peak: 137\u00b196% and 7\u00b16%, respectively) than after EC1 (146\u00a0\u00b1\u00a080% and 30\u00a0\u00b1\u00a021%, respectively), whereas BAP (bone formation marker) increased more after EC2 (18\u00a0\u00b1\u00a016%) than after EC1 (4\u00a0\u00b1\u00a015%) (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05). Leptin (49\u00a0\u00b1\u00a058%) and cOCN (14\u00a0\u00b1\u00a010%) increased more (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05) after EC2 than after EC1 (\u221230\u00a0\u00b1\u00a015%, 9\u00a0\u00b1\u00a026%). Significant (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05) correlations were evident between peak CK activity and peak CTX\u20101 (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.847), P1NP (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.815), BAP (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.707), ucOCN (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.627), cCON (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.759), and leptin (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.740) changes after EC1, but many of these correlations disappeared after EC2. This was also found for the relationships between other muscle damage markers (myoglobin, muscle soreness, and muscle strength) and the bone markers. It was concluded that bone turnover was affected by eccentric exercise, but muscle damage was unfavorable for bone formation.<\/jats:p>","DOI":"10.1111\/sms.14118","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T08:02:08Z","timestamp":1640332928000},"page":"521-532","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Changes in blood bone markers after the first and second bouts of whole\u2010body eccentric exercises"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7353-8560","authenticated-orcid":false,"given":"Tsang\u2010Hai","family":"Huang","sequence":"first","affiliation":[{"name":"Institute of Physical Education, Health and Leisure Studies National Cheng Kung University  Tainan City 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