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We therefore studied the association of physical activity with a comprehensive metabolic profile measured repeatedly in adolescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cohort is derived from the longitudinal Special Turku Coronary Risk Factor Intervention Project. At ages 13, 15, 17, and 19\u2009years, data on physical activity were collected by a questionnaire, and circulating metabolic measures were quantified by nuclear magnetic resonance metabolomics from repeatedly assessed serum samples (age 13: <jats:italic>n<\/jats:italic>\u00a0=\u00a0503, 15: <jats:italic>n<\/jats:italic>\u00a0=\u00a0472, 17: <jats:italic>n<\/jats:italic>\u00a0=\u00a0466, and 19: <jats:italic>n<\/jats:italic>\u00a0=\u00a0361).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Leisure\u2010time physical activity (LTPA;MET h\/wk) was directly associated with concentrations of polyunsaturated fatty acids, and inversely with the ratio of monounsaturated fatty acids to total fatty acids (\u22120.006SD; [\u22120.008, \u22120.003]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). LTPA was inversely associated with very\u2010low\u2010density lipoprotein (VLDL) particle concentration (\u22120.003SD; [\u22120.005, \u22120.001]; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) and VLDL particle size (\u22120.005SD; [\u22120.007, \u22120.003]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). LTPA showed direct association with the particle concentration and size of high\u2010density lipoprotein (HDL), and HDL cholesterol concentration (0.004SD; [0.002, 0.006]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Inverse associations of LTPA with triglyceride and total lipid concentrations in large to small sized VLDL subclasses were found. Weaker associations were seen for other metabolic measures including inverse associations with concentrations of lactate, isoleucine, glycoprotein acetylation, and a direct association with creatinine concentration. The results remained after adjusting for body mass index and proportions of energy intakes from macronutrients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Physical activity during adolescence is beneficially associated with the metabolic profile including novel markers. The results support recommendations on physical activity during adolescence to promote health and possibly reduce future disease risks.<\/jats:p><\/jats:sec>","DOI":"10.1111\/sms.14261","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T15:11:37Z","timestamp":1667574697000},"page":"307-318","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association of physical activity with metabolic profile from adolescence to adulthood"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0880-560X","authenticated-orcid":false,"given":"Miia","family":"Lehtovirta","sequence":"first","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine University of Turku  Turku Finland"},{"name":"Centre for Population Health Research University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feitong","family":"Wu","sequence":"additional","affiliation":[{"name":"Menzies Institute for Medical Research University of Tasmania  Hobart Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvi P.","family":"Rovio","sequence":"additional","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine University of Turku  Turku Finland"},{"name":"Centre for Population Health Research University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1722-1729","authenticated-orcid":false,"given":"Olli J.","family":"Heinonen","sequence":"additional","affiliation":[{"name":"Paavo Nurmi Centre, Unit for Health and Physical Activity University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomi T.","family":"Laitinen","sequence":"additional","affiliation":[{"name":"Research Centre of Applied and Preventive Cardiovascular Medicine University of Turku  Turku Finland"},{"name":"Centre for Population Health Research University of Turku and Turku University Hospital  Turku Finland"},{"name":"Paavo Nurmi Centre, Unit for Health and Physical Activity University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri","family":"Niinikoski","sequence":"additional","affiliation":[{"name":"Centre for Population Health Research University of Turku and Turku University Hospital  Turku Finland"},{"name":"Department of Pediatrics and Adolescent Medicine Turku University Hospital, University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Lagstr\u00f6m","sequence":"additional","affiliation":[{"name":"Centre for Population Health Research University of Turku and Turku University Hospital  Turku Finland"},{"name":"Department of Public Health University of Turku and Turku University Hospital  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorma S. 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