{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:35:03Z","timestamp":1791819303421,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Anthracycline chemotherapy is a frequent treatment for breast cancer, whereas it can increase risk of physiologic side\u2010effects, such as metabolic syndrome (MetS). Exercise has been used as a non\u2010pharmacological strategy to decrease MetS. Specifically, high\u2010intensity interval training (HIIT) has been shown to improve MetS in patients with diabetes or cardiac rehabilitation patients; however, the effects of HIIT on MetS and associated biomarkers in patients with breast cancer receiving anthracycline chemotherapy have not been previously explored. Therefore, we purposed to determine the effects of HIIT on MetS in breast cancer patients undergoing anthracycline chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 30 patients with breast cancer were recruited prior to initiating treatment and randomized into HIIT (<jats:italic>n<\/jats:italic>\u00a0=\u00a015) or control (<jats:italic>n<\/jats:italic>\u00a0=\u00a015). The HIIT group attended supervised cycling sessions 3\u2009days\/week for 8\u2009weeks. MetS was assessed by waist circumference, blood pressure, fasting levels of high\u2010density lipoprotein cholesterol (HDL\u2013C), triglycerides, and glucose. Circulating levels of MetS\u2010related biomarkers were also measured (total cholesterol, insulin, HbA1c, leptin, adiponectin, and c\u2010reactive protein).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 8\u2009weeks, MetS z\u2010score was significantly improved in the HIIT group compared with controls (\u22127.60, 95% CI: \u22129.08 to \u22126.13, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). MetS variables (HDL\u2013C, glucose, and triglycerides) and circulating levels of MetS\u2010related biomarkers were significantly improved in the HIIT group compared with controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Non\u2010significant differences were found in body composition outcomes at the end of the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HIIT may be an effective strategy to improve MetS in breast cancer patients undergoing anthracycline chemotherapy. Furthermore, changes in MetS were independent of changes in body composition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/sms.14280","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T19:48:55Z","timestamp":1669405735000},"page":"475-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["High\u2010intensity interval training improves metabolic syndrome in women with breast cancer receiving Anthracyclines"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5793-1437","authenticated-orcid":false,"given":"Paola","family":"Gonzalo\u2010Encabo","sequence":"first","affiliation":[{"name":"Division of Population Sciences, Department of Medical Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"},{"name":"Harvard Medical School  Massachusetts Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-0546","authenticated-orcid":false,"given":"Cami N.","family":"Christopher","sequence":"additional","affiliation":[{"name":"Division of Population Sciences, Department of Medical Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"},{"name":"Department of Epidemiology, School of Public Health Boston University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyuwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Population Sciences Beckman Research Institute, City of Hope  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber\u00a0J.","family":"Normann","sequence":"additional","affiliation":[{"name":"Division of Population Sciences, Department of Medical Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"},{"name":"Department of Health Sciences Boston University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra G.","family":"Yunker","sequence":"additional","affiliation":[{"name":"Division of Population Sciences, Department of Medical Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"},{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary K.","family":"Norris","sequence":"additional","affiliation":[{"name":"Division of Population Sciences, Department of Medical Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellice","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9093-7259","authenticated-orcid":false,"given":"Christina M.","family":"Dieli\u2010Conwright","sequence":"additional","affiliation":[{"name":"Division of Population Sciences, Department of Medical Oncology Dana\u2010Farber Cancer Institute  Boston Massachusetts USA"},{"name":"Harvard Medical School  Massachusetts Boston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.1273"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2019.1854"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.11.020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.7526"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-019-00747-z"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-020-00640-2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/met.2017.0042"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700968R"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5887-7"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61927-x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06294-7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-022622"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/168797"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001934"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001424"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-019-05332-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4178\/epih.e2017003"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01290"},{"key":"e_1_2_10_20_1","first-page":"1","article-title":"Prevalence of metabolic syndrome among adults 20\u2009years of age and over, by sex, age, race and ethnicity, and body mass index: United States, 2003\u20102006","volume":"13","author":"Ervin RB","year":"2009","journal-title":"Natl Health Stat Report"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-0300"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30104"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-019-0514-y"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-66513-9"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0602"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-020-05411-2"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735420977666"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00063.2017"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/0004-2730000003223"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2004.03.022"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165820"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300368-JLR200"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12281"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30729"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12609-016-0218-3"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01409-0"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17155445"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/59.4.m396"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-1652"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-020-04361-1"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.12.017"}],"container-title":["Scandinavian Journal of Medicine &amp; 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