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Before and after training, muscle sympathetic nerve activity (MSNA) and blood pressure were measured at rest and during a sympatho\u2010excitatory cold pressor test (CPT). Based on the measurements, baroreceptor sensitivity and baroreceptor threshold were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Resting MSNA and baroreceptor sensitivity were similar for the hypertensive and the normotensive groups. Training lowered MSNA (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), expressed as burst frequency (burst\/min), overall, and to a similar extent, in both groups (17% and 27%, respectively, in hypertensive and normotensive group), whereas blood pressure was only significantly (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) lowered (by 4\u2009mmHg in both systolic and diastolic pressure) in the hypertensive group. Training did not (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05) alter the MSNA or blood pressure response to CPT or increase baroreceptor sensitivity but reduced (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) the baroreceptor threshold with a main effect for both groups. Training adherence and intensity were similar in both groups yet absolute maximal oxygen uptake increased by 15% in the normotensive group only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The dissociation between the training induced changes in resting MSNA, lack of change in baroreflex sensitivity and the change in blood pressure, suggests that MSNA is not a main cause of the blood pressure reduction with exercise training in un\u2010medicated middle\u2010aged\/older men.<\/jats:p><\/jats:sec>","DOI":"10.1111\/sms.14300","type":"journal-article","created":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T17:58:55Z","timestamp":1672595935000},"page":"586-596","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sympathetic activity is not a main cause of blood pressure reduction with exercise training in un\u2010medicated middle\u2010aged\/older men"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9987-248X","authenticated-orcid":false,"given":"Thomas S.","family":"Ehlers","sequence":"first","affiliation":[{"name":"Department for Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3714-2227","authenticated-orcid":false,"given":"Sophie","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department for Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla C.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department for Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea S.","family":"Tamariz\u2010Ellemann","sequence":"additional","affiliation":[{"name":"Department for Nutrition, Exercise and Sports University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler D.","family":"Vermeulen","sequence":"additional","affiliation":[{"name":"School of Kinesiology Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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