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However, a clear answer to whether such a difference exists has not been established. Therefore, the aim of our paper was to overview methods and results of studies that compared acute changes in muscle strength after bouts of ECC<jats:sub>max<\/jats:sub>and CON<jats:sub>max<\/jats:sub>resistance exercise. We identified 30 relevant studies. Participants were typically healthy men aged 20\u201340\u2009years. Exercise usually consisted of 40\u2013100 isokinetic ECC<jats:sub>max<\/jats:sub>and CON<jats:sub>max<\/jats:sub>repetitions of the knee extensors or elbow flexors<jats:italic>.<\/jats:italic>Both ECC<jats:sub>max<\/jats:sub>and CON<jats:sub>max<\/jats:sub>exercise caused significant strength loss, which plateaued and rarely exceeded 60% of baseline, suggesting strength preservation. In upper\u2010body muscles, strength loss at the end of ECC<jats:sub>max<\/jats:sub>(31.4\u2009\u00b1\u200920.4%) and CON<jats:sub>max<\/jats:sub>(33.6\u2009\u00b1\u200917.5%) exercise was similar, whereas in lower\u2010body muscles, strength loss was less after ECC<jats:sub>max<\/jats:sub>(13.3\u2009\u00b1\u200912.2%) than CON<jats:sub>max<\/jats:sub>(39.7\u2009\u00b1\u200913.3%) exercise. Muscle architecture and daily use of lower\u2010body muscles likely protects lower\u2010body muscles from strength loss during ECC<jats:sub>max<\/jats:sub>exercise. We also reviewed seven studies on muscle fatigue during<jats:italic>coupled<\/jats:italic>ECC<jats:sub>max<\/jats:sub>\u2010CON<jats:sub>max<\/jats:sub>exercise and found similar strength loss in the ECC and CON phases. We also found evidence from three studies that more ECC than CON repetitions can be completed at equal<jats:italic>relative<\/jats:italic>loads. These results indicate that muscle fatigue may manifest differently between ECC<jats:sub>max<\/jats:sub>and CON<jats:sub>max<\/jats:sub>resistance exercise. An implication of the results is that prescriptions of ECC resistance exercise for lower\u2010body muscles should account for greater fatigue resilience of these muscles compared to upper\u2010body muscles.<\/jats:p>","DOI":"10.1111\/sms.14419","type":"journal-article","created":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T06:15:12Z","timestamp":1685772912000},"page":"1901-1915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Overview of muscle fatigue differences between maximal eccentric and concentric resistance exercise"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9081-0522","authenticated-orcid":false,"given":"James L.","family":"Nuzzo","sequence":"first","affiliation":[{"name":"School of Medical and Health Sciences Edith Cowan University Joondalup 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