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While evidence exists regarding the high physical demands on the hamstring muscles in HSR, meta\u2010analytical synthesis of related activation and kinetic variables is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search of Medline, Embase, Scopus, CINAHL, SportDiscus, and Cochrane library databases was conducted in accordance with the PRISMA 2020 guidelines. Studies reporting hamstring activation (electromyographic [EMG]) or hamstring muscle\/related joint kinetics were included where healthy adult participants ran at or beyond 60% of maximum speed (activation studies) or 4\u2009m per second (m\/s) (kinetic studies).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 96 studies met the inclusion criteria. Run intensities were categorized as \u201cslow,\u201d \u201cmoderate,\u201d or \u201cfast\u201d in both activation and kinetic based studies with appropriate relative, and raw measures, respectively. Meta\u2010analysis revealed pooled mean lateral hamstring muscle activation levels of 108.1% (95% CI: 84.4%\u2013131.7%) of maximal voluntary isometric contraction (MVIC) during \u201cfast\u201d running. Meta\u2010analysis found swing phase peak knee flexion internal moment and power at 2.2 Newton meters\/kilogram (Nm\/kg) (95% CI: 1.9\u20132.5) and 40.3 Watts\/kilogram (W\/kg) (95% CI: 31.4\u201349.2), respectively. Hip extension peak moment and power was estimated as 4.8\u2009Nm\/kg (95% CI: 3.9\u20135.7) and 33.1\u2009W\/kg (95% CI: 17.4\u201348.9), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>As run intensity\/speed increases, so do the activation and kinetic demands on the hamstrings. The presented data will enable clinicians to incorporate more objective measures into the design of injury prevention and return\u2010to\u2010play decision\u2010making strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/sms.14478","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T12:50:28Z","timestamp":1693918228000},"page":"2423-2443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Quantifying demands on the hamstrings during <scp>high\u2010speed<\/scp> running: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8448-4816","authenticated-orcid":false,"given":"Timothy","family":"McNally","sequence":"first","affiliation":[{"name":"Faculty of Medicine &amp; Health, Sydney School of Health Sciences, Discipline of Exercise &amp; Sport Science  Sydney New South Wales 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