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We aimed to explore the relationship between different domains of sedentary behaviors and new\u2010onset hypertension, investigate whether genetic susceptibility to hypertension modifies the relationship, and examine the extent to which the relationship is mediated by body mass index (BMI) and grip strength.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>212\u2009714 participants without baseline hypertension in the UK Biobank were enrolled. The three major sedentary behaviors (TV\u2010watching, nonoccupational computer use, and driving) were measured using touch screen questionnaires. The primary outcome was new\u2010onset hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median follow\u2010up of 11.9\u2009years, 13\u2009983 participants developed hypertension. There was a linear positive association between TV\u2010watching time and new\u2010onset hypertension (<jats:italic>p<\/jats:italic> for nonlinearity =0.868). A J\u2010shaped association was found for nonoccupational computer use time and driving time with new\u2010onset hypertension, with an inflection point of 0.5\u2009h\/day for both (both <jats:italic>p<\/jats:italic> for nonlinearity &lt;0.001). Polygenetic risk scores for hypertension (based on 118 related single\u2010nucleotide polymorphisms) did not significantly modify these associations (all <jats:italic>p<\/jats:italic>\u2010interactions &gt;0.05). Furthermore, the detrimental effects of long\u2010term sedentary behaviors on hypertension were mediated by BMI by 21%\u201330%, and the beneficial effects of limited sitting time (within 0.5\u2009h\/day) for driving and nonoccupational computer use were mediated by grip strength by 6\u201325%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was a positive association for hands\u2010independence sedentary behavior (TV\u2010watching), and a J\u2010shaped association for hands\u2010dependence sedentary behaviors (nonoccupational computer use and driving) with new\u2010onset hypertension, regardless of genetic risks of hypertension. These relationships were partly mediated by BMI and grip strength.<\/jats:p><\/jats:sec>","DOI":"10.1111\/sms.14539","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T09:08:51Z","timestamp":1700212131000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Different sedentary behaviors, genetic susceptibility of hypertension, and new\u2010onset hypertension: Mediating effects of body mass index and grip strength"],"prefix":"10.1111","volume":"34","author":[{"given":"Sisi","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Nephrology Nanfang Hospital, Southern Medical University  Guangzhou China"},{"name":"National Clinical Research Center for Kidney Disease  Guangzhou China"},{"name":"State Key Laboratory of Organ Failure Research  Guangzhou China"},{"name":"Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziliang","family":"Ye","sequence":"additional","affiliation":[{"name":"Division of Nephrology Nanfang Hospital, Southern Medical University  Guangzhou China"},{"name":"National Clinical Research Center for Kidney Disease  Guangzhou China"},{"name":"State Key Laboratory of Organ Failure Research  Guangzhou China"},{"name":"Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Nephrology Nanfang Hospital, Southern Medical 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