{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:25:11Z","timestamp":1791563111202,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007109","name":"Universit\u00e0 degli Studi di Ferrara","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007109","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this single\u2010blinded randomized controlled trial, we compared the \u201cTest in\u2010Train Out\u201d structured home\u2010based exercise program (TiTo\u2010SHB) with the traditional \u201cgo home and walk\u201d exercise intervention in people with peripheral artery disease (PAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Peripheral artery disease patients at Leriche\u2010Fontaine's stage II were randomized to receive TiTo\u2010SHB or walking advice (C\u2010WA). The TiTo\u2010SHB group performed two daily 8\u2010min sessions of pain\u2010free interval walking at progressive low\u2010to\u2010moderate speed maintained with a metronome. The C\u2010WA group was recommended to walk for 30\u2009min at least three times per week and to endure claudication pain. Outcomes collected at baseline and at the end of the program (6 months) included: 6\u2010min and pain\u2010free walking distance (6MWD, PFWD), ankle\u2010brachial index (ABI), 5\u2010time sit\u2010to\u2010stand test (5STS), and health\u2010related quality of life (HRQoL) by the VascuQoL\u20106 questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 68 patients were randomized (males\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200950; aged 73\u2009\u00b1\u20099; TiTo\u2010SHB\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934). At the end of the program, patients in the TiTo\u2010SHB group compared with the C\u2010WA group had significantly improved 6MWD (\u0394\u2009+\u200960\u2009\u00b1\u200932\u2009m vs. \u0394\u2009\u2212\u20095\u2009\u00b1\u200937\u2009m;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and PFWD (\u0394\u2009+\u2009140\u2009\u00b1\u200992\u2009m vs. \u0394\u2009\u2212\u20097\u2009\u00b1\u200987\u2009m;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). A significant between\u2010group difference in favor of the TiTo\u2010SHB group was also recorded for all the secondary outcomes, including 5STS (\u0394\u2009\u2212\u20092.6\u2009\u00b1\u20091.8\u2009s vs. \u0394\u2009+\u20090.8\u2009\u00b1\u20092.6\u2009s;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), ABI of the more impaired limb (\u0394\u2009+\u20090.10\u2009\u00b1\u20090.11 vs. \u0394\u2009+\u20090.02\u2009\u00b1\u20090.08;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), and VascuQoL\u20106 score (\u0394\u2009+2\u2009\u00b1\u20092 vs. \u22121\u2009\u00b1\u20094;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In PAD patients with claudication, the pain\u2010free in\u2010home TiTo\u2010SHB program was more effective in improving exercise capacity and HRQoL than the traditional walking advice recommendation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/sms.14584","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T08:23:50Z","timestamp":1707812630000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A \u201ctest in\u2010train out\u201d program versus a \u201cgo home and walk\u201d intervention for home\u2010based exercise therapy in patients with peripheral artery disease: A randomized controlled trial"],"prefix":"10.1111","volume":"34","author":[{"given":"Fabio","family":"Manfredini","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Rehabilitation University of Ferrara  Ferrara Italy"},{"name":"Program of Vascular Rehabilitation and Exercise Medicine University Hospital of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Traina","sequence":"additional","affiliation":[{"name":"Unit of Vascular and Endovascular Surgery University Hospital of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Ficarra","sequence":"additional","affiliation":[{"name":"Unit of Vascular and Endovascular Surgery University Hospital of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Gandolfi","sequence":"additional","affiliation":[{"name":"School of Sports and Exercise Medicine University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Argentoni","sequence":"additional","affiliation":[{"name":"School of Sports and Exercise Medicine University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Straudi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Rehabilitation University of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Gasbarro","sequence":"additional","affiliation":[{"name":"Unit of Vascular and Endovascular Surgery University Hospital of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5763-3069","authenticated-orcid":false,"given":"Nicola","family":"Lamberti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Rehabilitation University of Ferrara  Ferrara Italy"},{"name":"Program of Vascular Rehabilitation and Exercise Medicine University Hospital of Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.007"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(19)30255-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.179"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx095"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000623"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.2457"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2014.09.009"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2012.09.009"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X211060388"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2021.03.063"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.3275"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.72.946"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-1311"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0003319715618481"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-021-02827-4"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-019-02176-3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016030378"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.23736\/S1973-9087.16.04322-7"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13764"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/mps4020029"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.007002"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318276fbcb"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2466\/pms.103.1.215-222"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2013.08.099"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X18762599"},{"issue":"4","key":"e_1_2_10_28_1","article-title":"Supervised exercise therapy versus home\u2010based exercise therapy versus walking advice for intermittent claudication","volume":"4","author":"Hageman D","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.2536"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2020.03.052"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.5535\/arm.2012.36.3.386"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2021.10.031"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X21989430"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.07.002"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvscit.2023.101179"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00035.2004"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00014.2016"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2012.067967"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2009.06.011"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-1327"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00135"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000711"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000000673"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.963066"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001107"},{"key":"e_1_2_10_46_1","first-page":"2683","article-title":"Inequity in exercise\u2010based interventions for adults with intermittent claudication due to peripheral arterial disease: a systematic review","volume":"1","author":"Bearne LM","year":"2022","journal-title":"Disabil Rehabil"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjcn\/zvac070"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2021.106624"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2014.03.003"}],"container-title":["Scandinavian Journal of Medicine &amp; Science in Sports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sms.14584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T08:48:51Z","timestamp":1708937331000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sms.14584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/sms.14584"],"URL":"https:\/\/doi.org\/10.1111\/sms.14584","archive":["Portico"],"relation":{},"ISSN":["0905-7188","1600-0838"],"issn-type":[{"value":"0905-7188","type":"print"},{"value":"1600-0838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2023-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14584"}}