{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T01:46:24Z","timestamp":1784598384049,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R026505\/1"],"award-info":[{"award-number":["MR\/R026505\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/R026505\/2"],"award-info":[{"award-number":["MR\/R026505\/2"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["SP\/13\/2\/30111"],"award-info":[{"award-number":["SP\/13\/2\/30111"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypertension is a leading risk factor for cardiovascular disease and is modulated by genetic variants. This study aimed to assess the effect of obesity genetic liability and physical activity on hypertension among European and African ancestry individuals within the UK Biobank (UKB). Participants were 230\u2009115 individuals of European ancestry and 3239 individuals of African ancestry from UKB. Genetic liability for obesity were estimated using previously published data including genetic variants and effect sizes for body mass index (BMI), waist\u2010hip ratio (WHR) and waist circumference (WC) using Plink software. The outcome was defined as stage 2 hypertension (systolic blood pressure\u2009\u2265\u2009140\u2009mmHg, diastolic blood pressure \u226590\u2009mmHg, or the use of anti\u2010hypertensive medications). The association between obesity genetic liability and the outcome was assessed across categories of self\u2010reported physical activity using logistic regression. Among European ancestry participants, there was up to a 1.2 greater odds of hypertension in individuals with high genetic liability and low physical activity compared to individuals with low genetic liability and high physical activity (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In individuals engaging in low levels of physical activity compared with moderate\/high physical activity, the effect of BMI genetic liability on hypertension was greater (<jats:italic>p<\/jats:italic> <jats:sub>interaction<\/jats:sub>\u2009=\u20090.04). There was no evidence of an association between obesity genetic liability and hypertension in individuals of African ancestry in the whole sample or within separate physical activity groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). This study suggests that higher physical activity levels are associated with lower odds of stage 2 hypertension among European ancestry individuals who carry high genetic liability for obesity. This cannot be inferred for individuals of African ancestry, possibly due to the low African ancestry sample size within the UKB.<\/jats:p>","DOI":"10.1111\/sms.14636","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T03:45:27Z","timestamp":1714189527000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Physical activity alters the effect of genetic determinants of adiposity on hypertension among individuals of European ancestry in the UKB"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0734-0188","authenticated-orcid":false,"given":"Chukwueloka","family":"Hezekiah","sequence":"first","affiliation":[{"name":"Cardiovascular and Metabolic Research Group, Division of Biomedical Sciences, Department of Life Sciences, College of Health, Medicine and Life Sciences Brunel University London  London UK"},{"name":"Department of Mental Health, Faculty of Health, Science, Social Care and Education Kingston University  Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra I.","family":"Blakemore","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Centre for Cognitive Neuroscience, College of Health, Medicine and Life Sciences Brunel University London  London UK"},{"name":"Department of Metabolism Digestion and Reproduction, Imperial College London  London UK"},{"name":"School of Medicine University of Ireland  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3772-630X","authenticated-orcid":false,"given":"Daniel P.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Centre for Physical Activity in Health and Disease, College of Health, Medicine and Life Sciences Brunel University London  Uxbridge UK"},{"name":"Division of Sport, Health and Exercise Sciences, Department of Life Sciences Brunel University London  Uxbridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5142-2348","authenticated-orcid":false,"given":"Raha","family":"Pazoki","sequence":"additional","affiliation":[{"name":"Cardiovascular and Metabolic Research Group, Division of Biomedical Sciences, Department of Life Sciences, College of Health, Medicine and Life Sciences Brunel University London  London UK"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15026"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17570"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185225"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0154894"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12889-018-5443-4"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8157858"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12872-017-0737-5"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PMEDR.2021.101458"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.4314\/EJHS.V24I2.8"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.020405"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008405"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12955-018-1008-6"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/271532"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-018-0042-5"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0205-x"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.16471"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.121.003375"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.2337\/DB17-0573\/-\/DC1"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/NUTD.2014.33"},{"key":"e_1_2_13_21_1","unstructured":"UK Biobank.UK Biobank: Protocol for a Large\u2010Scale Prospective Epidemiological Resource (AMENDMENT ONE FINAL).2007."},{"key":"e_1_2_13_22_1","doi-asserted-by":"crossref","unstructured":"BycroftC FreemanC PetkovaD et\u00a0al.Genome\u2010wide genetic data on ~500 000 UK Biobank participants.bioRxiv. Published online July 20 2017:166298. doi:10.1101\/166298","DOI":"10.1101\/166298"},{"key":"e_1_2_13_23_1","unstructured":"MarchiniJ O'ConnellJ DelaneauO SharpK et\u00a0al.UK Biobank Phasing and Imputation Documentation Contributors to UK Biobank Phasing and Imputation.https:\/\/www.jiscmail.ac.uk\/cgi\u2010bin\/webadmin?A0=UKB\u2010GENETICS. Published online 2015. Accessed October 22 2022"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/S12864-016-3391-X"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym276"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030898"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/SIM.2165"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.11.005"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010038"},{"key":"e_1_2_13_31_1","unstructured":"IPAQ.Guidelines for Data Processing and Analysis of the International Physical Activity Questionnaire (IPAQ)\u2010Short and Long Forms.2005www.ipaq.ki.se"},{"key":"e_1_2_13_32_1","unstructured":"World Health Organisation.WHO GUIDELINES ON PHYSICAL ACTIVITY AND SEDENTARY BEHAVIOUR. Published online 2020. Accessed March 14 2024.https:\/\/iris.who.int\/bitstream\/handle\/10665\/336656\/9789240015128\u2010eng.pdf?sequence=1"},{"key":"e_1_2_13_33_1","unstructured":"UK Biobank.Showcase: data\u2010field 20161.2016Accessed June 29 2023.https:\/\/biobank.ndph.ox.ac.uk\/showcase\/field.cgi?id=20161"},{"key":"e_1_2_13_34_1","unstructured":"UK Biobank.UK Biobank Biomarker assay quality procedures: approaches used to minimise systematic and random errors (and the wider epidemiological implications).http:\/\/www.ukbiobank.ac.uk\/. Published online 2019. Accessed October 22 2022.http:\/\/www.ukbiobank.ac.uk\/"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PGEN.1005378"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PGEN.1006719"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14132"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PGEN.1003681"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_13_40_1","first-page":"281","volume-title":"Fifth Berkeley Symposium on Mathematical Statistics and Probability","author":"MacQueen J","year":"1967"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11121-015-0561-Z"},{"issue":"3","key":"e_1_2_13_42_1","first-page":"1","article-title":"mice: Multivariate imputation by chained equations in R","volume":"45","author":"Van Buuren S","year":"2011","journal-title":"J Stat Softw"},{"key":"e_1_2_13_43_1","unstructured":"R Core Team.R: The R Project for Statistical Computing. Published 2021. Accessed September 23 2021.https:\/\/www.r\u2010project.org\/"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41598-017-11037-Y"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08398"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0200630"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803576"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/AJE\/KWX246"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.03.010"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023143"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/S10433-021-00657-Z\/TABLES\/6"}],"container-title":["Scandinavian Journal of Medicine &amp; Science in Sports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/sms.14636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T07:33:34Z","timestamp":1716363214000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/sms.14636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,26]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/sms.14636"],"URL":"https:\/\/doi.org\/10.1111\/sms.14636","archive":["Portico"],"relation":{},"ISSN":["0905-7188","1600-0838"],"issn-type":[{"value":"0905-7188","type":"print"},{"value":"1600-0838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,26]]},"assertion":[{"value":"2024-01-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14636"}}