{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:31:48Z","timestamp":1789468308083,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although individuals with anterior cruciate ligament reconstruction (ACLR) are at high risk for posttraumatic osteoarthritis, mechanisms underlying the relationship between running and knee cartilage health remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to investigate how 30\u2009min of running influences femoral cartilage thickness and composition and their relationships with running biomechanics in patients with ACLR and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty patients with ACLR (time post\u2010ACLR: 14.6\u2009\u00b1\u20096.1\u2009months) and 20 matched controls participated in the study. A running session required both groups to run for 30\u2009min at a self\u2010selected speed. Before and after running, we measured femoral cartilage thickness via ultrasound imaging. A MRI session consisted of T2 mapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ACLR group showed longer T2 relaxation times in the medial femoral condyle at resting compared with the control group (central: 51.2\u2009\u00b1\u200916.6 vs. 34.9\u2009\u00b1\u200913.2\u2009ms, <jats:italic>p<\/jats:italic>\u2009=\u20090.006; posterior: 50.2\u2009\u00b1\u200910.1 vs. 39.8\u2009\u00b1\u20097.4\u2009ms, <jats:italic>p<\/jats:italic>\u2009=\u20090.006). Following the run, the ACLR group showed greater deformation in the medial femoral cartilage than the control group (0.03\u2009\u00b1\u20090.01 vs. 0.01\u2009\u00b1\u20090.01\u2009cm, <jats:italic>p<\/jats:italic>\u2009=\u20090.001). Additionally, the ACLR group showed significant negative correlations between resting T2 relaxation time in the medial femoral condyle and vertical impulse (standardized regression coefficients\u2009=\u2009\u22120.99 and <jats:italic>p<\/jats:italic>\u2009=\u20090.004) during running.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that those who are between 6 and 24\u2009months post\u2010ACLR have degraded cartilage composition and their cartilage deforms more due to running vGRF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/sms.14675","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T11:14:07Z","timestamp":1718190847000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Relationships Between Running Biomechanics and Femoral Articular Cartilage Thickness and Composition in Anterior Cruciate Ligament Reconstruction Patients"],"prefix":"10.1111","volume":"34","author":[{"given":"Hyunwook","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Exercise and Sport Science University of North Carolina at Chapel Hill  Chapel Hill North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dallin","family":"Clinger","sequence":"additional","affiliation":[{"name":"Department of Exercise Sciences Brigham Young University  Provo Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9123-3402","authenticated-orcid":false,"given":"Minsub","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Exercise Sciences Brigham Young University  Provo Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunguk","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Sport Science Pusan National University  Pusan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven\u00a0P.","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Electric and Computer Engineering Brigham Young University  Provo Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garritt\u00a0L.","family":"Page","sequence":"additional","affiliation":[{"name":"Department of Statistics Brigham Young University  Provo Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin\u00a0A.","family":"Bruening","sequence":"additional","affiliation":[{"name":"Department of Exercise Sciences Brigham Young University  Provo Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert\u00a0D.","family":"Hyldahl","sequence":"additional","affiliation":[{"name":"Department of Exercise Sciences Brigham Young University  Provo Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u00a0Ty","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Department of Exercise Sciences Brigham Young University  Provo Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew\u00a0K.","family":"Seeley","sequence":"additional","affiliation":[{"name":"Department of Exercise Sciences Brigham Young University  Provo Utah 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