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The invasive measure has offered important insight into leg hemodynamics and blood flow distribution during exercise. Despite being the natural modality of exercise in humans, there has been no direct measure of Q\u0307<jats:sub>LEG<\/jats:sub> while running in humans. We sought to determine the feasibility of the thermodilution technique for measuring Q\u0307<jats:sub>LEG<\/jats:sub> and conductance during high\u2010intensity running, in an exploratory case study. A trained runner (30\u2009years male) completed two maximal incremental tests on a cycle ergometer and motorized treadmill. Q\u0307<jats:sub>LEG<\/jats:sub> and Q\u0307<jats:sub>C<\/jats:sub> were determined using the single\u2010bolus thermodilution technique. Arterial and venous blood were sampled throughout exercise, with continuous monitoring of metabolism, intra\u2010arterial and venous pressure, and temperature. The participant reached a greater peak oxygen uptake (V\u0307O<jats:sub>2peak<\/jats:sub>) during running relative to cycling (74 vs. 68\u2009mL\/kg\/min) with comparable Q\u0307<jats:sub>LEG<\/jats:sub> (19.0 vs. 19.5\u2009L\/min) and Q\u0307<jats:sub>C<\/jats:sub> (27.4 vs. 26.2\u2009L\/min). Leg vascular conductance was greater during high\u2010intensity running relative to cycling (82 vs. 70\u2009mL\/min\/mmHg @ ~80% V\u0307O<jats:sub>2peak<\/jats:sub>). The \u201cbeat phenomenon\u201d was apparent in femoral flow while running, producing large gradients in conductance (62\u201390\u2009mL\/min\/mmHg @ 70% V\u0307O<jats:sub>2peak<\/jats:sub>). In summary, we present the first direct measure of Q\u0307<jats:sub>LEG<\/jats:sub> and conductance in a running human. Our findings corroborate several assumptions about Q\u0307<jats:sub>LEG<\/jats:sub> during running compared with cycling. Importantly, we demonstrate that using thermodilution in running exercise can be completed effectively and safely.<\/jats:p>","DOI":"10.1111\/sms.14705","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T12:02:44Z","timestamp":1721995364000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessing Leg Blood Flow and Cardiac Output During Running Using Thermodilution"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9209-3982","authenticated-orcid":false,"given":"Michael\u00a0G.","family":"Leahy","sequence":"first","affiliation":[{"name":"School of Kinesiology, Faculty of Education University of British Columbia  Vancouver Canada"},{"name":"Department of Internal Medicine University of Texas Southwestern Medical Centre  Dallas Texas USA"},{"name":"Institute for Exercise and Environmental Medicine Texas Presbyterian Hospital  Dallas Texas 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