{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:17:37Z","timestamp":1790846257726,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Scandinavian Med Sci Sports"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We explored the impact of running in the severe intensity domain on running mechanics and muscle oxygenation in competitive runners by investigating the relationship between mechanical deviations from typical stride characteristics and muscle oxygen saturation (SmO<jats:sub>2<\/jats:sub>) in the quadriceps muscle. Sixteen youth competitive runners performed an 8\u2010min exhaustive running test on an outdoor track. Running mechanics were continuously monitored using inertial measurement units. Rectus femoris SmO<jats:sub>2<\/jats:sub> and total hemoglobin (a measure of blood volume) were continuously monitored by near\u2010infrared spectroscopy. One\u2010class support vector machine (OCSVM) modeling was employed for subject\u2010specific analysis of the kinematic data. Statistical analysis included principal component analysis, ANOVA, and correlation analysis. Mechanical deviations from typical stride characteristics increased as the running test progressed. Specifically, the percentage of outliers in the OCSVM model rose gradually from 2.2\u2009\u00b1\u20090.8% at the start to 43.6\u2009\u00b1\u200928.2% at the end (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, mean\u2009\u00b1\u2009SD throughout). SmO<jats:sub>2<\/jats:sub> dropped from 74.3\u2009\u00b1\u20098.4% at baseline to 10.1\u2009\u00b1\u20096.8% at the end (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). A moderate negative correlation (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.61, <jats:italic>p<\/jats:italic>\u2009=\u20090.013) was found between the average SmO<jats:sub>2<\/jats:sub> and the percentage of outlier strides during the last 15% of the run. During high\u2010intensity running, alterations in running biomechanics may occur, linked to decreased quadriceps muscle oxygenation. These parameters highlight the potential of using running kinematics and muscle oxygenation in training to optimize performance and reduce injury risks. Our research contributes to understanding biomechanical and physiological responses to endurance running and emphasizes the importance of individualized monitoring.<\/jats:p>","DOI":"10.1111\/sms.14709","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T10:39:51Z","timestamp":1723459191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mechanical Deviations in Stride Characteristics During Running in the Severe Intensity Domain Are Associated With a Decline in Muscle Oxygenation"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0886-5936","authenticated-orcid":false,"given":"Christos","family":"Chalitsios","sequence":"first","affiliation":[{"name":"Biomechanics Laboratory, School of Physical Education and Sports Science at Thessaloniki Aristotle University of Thessaloniki  Thessaloniki Greece"},{"name":"R&amp;D Kinvent \u2013 Biomechanique  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5305-1472","authenticated-orcid":false,"given":"Thomas","family":"Nikodelis","sequence":"additional","affiliation":[{"name":"Biomechanics Laboratory, School of Physical Education and Sports Science at Thessaloniki Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8430-7231","authenticated-orcid":false,"given":"Vassilis","family":"Mougios","sequence":"additional","affiliation":[{"name":"Laboratory of Evaluation of Human Biological Performance, School of Physical Education and Sports Science at Thessaloniki Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000929"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318259480d"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-011-2661-8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2009.04.012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-007-0589-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00584-9"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2006.12.003"},{"issue":"4","key":"e_1_2_9_9_1","first-page":"328","article-title":"Functional Variability of the Lower Extremity During the Support Phase of Running","volume":"11","author":"Bates B. 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